3-メチル-1,2-ジヒドロベンゾ[j]アセアントリレン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H350：発がんのおそれ

  H413：長期的影響により水生生物に有害のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P273：環境への放出を避けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

3-メチル-1,2-ジヒドロベンゾ[j]アセアントリレン 価格

3-メチル-1,2-ジヒドロベンゾ[j]アセアントリレン 化学特性,用途語,生産方法

• 説明

  3-Methylcholanthrene (3-MC) is a member of the polycyclic aromatic hydrocarbon (PAH) family and is used as an experimental cancer research chemical. As other PAHs, 3-MC might be found in trace quantities in coal tar and heavy-end petroleum hydrocarbons.

• 化学的特性

  3-Methylcholanthrene is a solid that crystallizes from benzene and ether as pale yellow prisms. 3-methylcholanthrene is insoluble in water and soluble in alcohol. It is combustible, and can react with oxidizing materials.

• 使用

  3-Methylcholanthrene has been used to assess its tumor initiation activity by Bhas 42 cell transformation assay. It has also been used to induce the activity of cytochrome P450.

• 定義

  ChEBI: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.

• 一般的な説明

  Yellow crystals or solid.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  3-METHYLCHOLANTHRENE can react with oxidizing materials. Ozone and chlorinating agents oxidize 3-METHYLCHOLANTHRENE.

• 危険性

  Powerful carcinogen.

• 火災危険

  Flash point data for 3-METHYLCHOLANTHRENE are not available; however, 3-METHYLCHOLANTHRENE is probably combustible.

• 安全性プロファイル

  Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

• 職業ばく露

  The coke-oven plant is the principal source of coal tar. The hot gases and vapors produced during the conversion of coal to coke are collected by means of a scrubber, which condenses the effluent into ammonia, water, crude tar, and other by-products. Crude tar is separated from the remainder of the condensate for refining and may undergo further processing. Employees may be exposed to pitch and creosote in metal and foundry operations; when installing electrical equipment; in construction, railway, utility; and briquette manufacturing.

• 発がん性

  3-Methylcholanthrene is a rapid, all-around neoplastic agent and a potent liver tumorigen.

• 環境運命予測

  3-MC, when released to soil, adsorbs strongly to the soil and does not leach. It does not biodegrade or hydrolyze significantly but may evaporate from dry soil. If released to water, it is expected to adsorb strongly to sediment and to bioconcentrate in aquatic organisms. If released into the atmosphere, it may be subject to direct photolysis because it absorbs strongly in the ultraviolet (UV) spectrum of light. It may also react with peroxyl radicals already present in the atmosphere. Its estimated half-life in the atmosphere is 2.8 h. Considering an octanol/ water log concentration ratio of 6.42, a bioconcentration factor of 45 000 has been estimated.

• 輸送方法

  UN1136 Coal tar distillates, flammable, Hazard Class: 3; Labels: 3-Flammable liquid

• 不和合性

  Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Phenols, such as creosote react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Flammable hydrogen gas is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid

• 廃棄物の処理

  Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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