ビス(α-メチル-1-ナフタレン酢酸)2,2'-(1,4-ピペラジンジイル)ビスエチル

ビス(α-メチル-1-ナフタレン酢酸)2,2'-(1,4-ピペラジンジイル)ビスエチル 化学特性,用途語,生産方法

• Originator

  Naftidan,De Angeli,Italy,1969

• Manufacturing Process

  15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.

• Therapeutic Function

  Spasmolytic

ビス(α-メチル-1-ナフタレン酢酸)2,2'-(1,4-ピペラジンジイル)ビスエチル 上流と下流の製品情報

ビス(α-メチル-1-ナフタレン酢酸)2,2'-(1,4-ピペラジンジイル)ビスエチル 生産企業

Global(6)Suppliers

5061-22-3, ビス(α-メチル-1-ナフタレン酢酸)2,2'-(1,4-ピペラジンジイル)ビスエチル キーワード