ソルビン酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

ソルビン酸 価格

MSDS Information

• Sorbic acid

ソルビン酸 化学特性,用途語,生産方法

• 外観

  白色〜ほとんど白色, 結晶〜結晶性粉末

• 定義

  本品は、次の化学式で表される有機酸である。

• 溶解性

  エタノール及びジエチルエーテルに溶け、水にほとんど溶けない。水に微溶 (30℃で0.25%)。エタノールに12.5%, メタノールに20%可溶。

• 解説

  ソルビン酸，白色の針状晶．融点134.5 ℃，沸点228 ℃(分解)．エタノール，エーテル，アセトンに可溶，水に難溶．かび，酵母，好気性菌に対して発育阻止作用があり，保存料，防腐剤として食品に用いられる．合成樹脂原料などにも用いられる．LD50 10.5 g/kg(ラット，経口)．
  

  森北出版「化学辞典（第2版）
  

• 用途

  防腐剤、保存料

• 用途

  中性または酸性で抗カビ力がすぐれ、特定食品の抗カビ剤に用いられる。また合成樹脂の原料にもなる。

• 製法

  ソルビン酸，天然には，ナナカマドSorbus commixta H.の果実中に存在する．クロトンアルデヒドとマロン酸のピリジン中での縮合，あるいはアセトアルデヒド3分子から(順次アルドール結合と脱水を経て)誘導される．ヘキサジエナールの空気酸化でも得られ，市販品はtrans-trans形である．

• 化粧品の成分用途

  防腐剤、香料

• 効能

  抗菌性保存剤

• 毒性

  LD50 10.5 g/kg(ラット，経口)．

• 使用上の注意

  重合しやすい。

• 化学的特性

  White, crystalline solid. Slightly soluble in water and many organic solvents. Combustible.

• 来歴

  Sorbic acid is a white crystalline solid first isolated in 1859 by hydrolysis of the oil distilled from unripened mountain-ash berries. The name is derived from the scientific term for the rowan tree, Sorbus aucuparia Linne, which is the parent plant of the mountain ash. Sorbic acid was first synthesized in 1900. Interest in this compound was minimal until independent researchers, E. Mueller of Germany and C.M. Gooding of the United States, discovered its antimicrobial effect in 1939 and 1940, respectively. Early interest in manufacturing sorbic acid centered around its use as a tung oil replacement when tung oil supplies were curtailed in the United States during World War II. High manufacturing costs prohibited expanded use until its approval as a food preservative in 1953. Sorbic acid is widely used in foods having a pH of 6.5 or below, where control of bacteria, molds, and yeasts is essential for obtaining safe and economical storage life.

• 使用

  Sorbic Acid is an naturally occurring organic compound first isolated from unripe berries. Sorbic acid has been used as a food preservative and as an inhibitor of Clostridium Botulinum bacteria in mea t products in order to reduce the amount of nitrites which produce carcinogenic nitroamines.

• 定義

  ChEBI: A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometri isomers possible, as well as the one with the highest antimicrobial activity.

• 反応性

  The chemical reactivity of sorbic acid is determined by the conjugated double bonds and the carboxyl group.
  Sorbic acid is brominated faster than other olefinic acids. Reaction with hydrogen chloride gives predominately 5-chloro-3-hexenoic acid. Reactions with amines at high temperatures under pressure lead to mixtures of dehydro-2-piperidinones. A yellow crystalline complex is formed from sorbic acid and iron tricarbonyl. Similar coordination occurs also in the presence of other di- and trivalent metals. Reduction of the double bonds can produce various hexenoic acid mixtures.

• 一般的な説明

  White powder or crystals. Melting point 134.5°C. Slightly acidic and astringent taste with a faint odor.

• 空気と水の反応

  Soluble in hot water [Handbook of Chemistry and Physics]. May be sensitive to exposure to air and heat. The dust may become explosive, particularly when mixed with free-radical initiators or oxidizing agents. .

• 反応プロフィール

  Sorbic acid may discolor on exposure to light. Can react with oxidizing agents. Also incompatible with bases and reducing agents. The dust may become explosive, particularly when mixed with free-radical initiators or oxidizing agents .

• 火災危険

  Sorbic acid is combustible.

• 安全性プロファイル

  Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. Experimental reproductive effects. A severe human and experimental skin irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use water. When heated to decomposition it emits acrid smoke and irritating fumes.

• 発がん性

  Wistar rats (six males) given subcutaneous injections of 2mg sorbic acid, in 0.5mL of arachis oil twice weekly for 65 weeks developed local sarcomas . The first tumor was observed at 82 weeks. Similar findings were also observed in follow-up studies . However, six Wistar rats maintained on drinking water containing 10 mg of sorbic acid/100mL drinking water for 64 weeks did not develop tumors. Tumors also were not observed inWistar rats (50 of each sex) on diets that contained 40 mg/kg/day of sorbic acid for 18 months or in 25 male and female cross-bred white mice after administration of 40 mg/kg/day for 17 months.
  Mice fed a diet containing 15% sorbic acid for 88 weeks exhibited a high incidence of hepatoma. Furthermore, the glutathione level in the livers of the mice that ingested 15% sorbic acid decreased to 40% of the amount found in controls after a 3-month feeding period; this low level was maintained until the end of the experiments at 12 months. There was a close correlation between the extent of depletion of the glutathione level in the liver and the concentration of sorbic acid added to the diet. In the same strain of mice fed a diet containing 15% sorbic acid for up to 6 months, the acidic fraction of an ether extract showed slight mutagenic activity in an Ames test with Salmonella typhimurium TA98 in the presence of a liver 9000-g supernatant. Consequently, the hepatomas that developed in mice fed a 15% sorbic acid diet were considered to be induced both by the chronic depletion of the hepatic glutathione and by the gradual production of various promutagens in the intestine, which were absorbed and metabolically activated by the liver.

• 純化方法

  Crystallise the acid from water. Dry it air or in a desiccator over P2O5. [Beilstein 2 IV 1701.]

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ソルビン酸 スペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

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