Uses
Antiparkinsonian (D2receptor agonist).
Definition
ChEBI: Ropinirole is a member of indolones and a tertiary amine. It has a role as a dopamine agonist, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent.
brand name
Requip (GlaxoSmithKline).
Synthesis Reference(s)
Journal of Medicinal Chemistry, 28, p. 1533, 1985
DOI: 10.1021/jm00148a028
Clinical Use
Anti-Parkinson agent
Restless legs syndrome (RLS)
Drug interactions
Potentially hazardous interactions with other drugs
Antipsychotics: antagonism of anti-Parkinsonian
effect - avoid.
Metoclopramide: antagonism of anti-Parkinsonian
effect - avoid.
Oestrogens: concentration increased.
Metabolism
Ropinirole is hepatically metabolised by the cytochrome
P450 enzyme, CYP1A2, and excreted in the urine as
inactive metabolites.
