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1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Structure

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

Chemical Properties

Melting point aprox. 36°C
Boiling point 128-132 °C12 mm Hg(lit.)
Density  1.001±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
form  Solid
pka 8.66±0.40(Predicted)
color  Pale Yellow to Light Yellow
Merck  13,6319
Stability Stable. Incompatible with strong oxidizing agents.
FDA UNII 9P21XSP91P

Safety

Symbol(GHS)
Signal wordDanger
Hazard statements H370-H301
Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501
Hazard Codes  T
Risk Statements  25-39/23/24/25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  UT8358900
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 28289-54-5(Hazardous Substances Data)
Toxicity Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Price

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Chemical Properties,Usage,Production

Preparation Products And Raw materials

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