RILPIVIRINE HCL
- Product NameRILPIVIRINE HCL
- CAS700361-47-3
- CBNumberCB62455679
- MFC22H19ClN6
- MW402.89
- MDL NumberMFCD11046523
- MOL File700361-47-3.mol
- MSDS FileSDS
Chemical Properties
storage temp. | Store at -20°C |
solubility | DMSO:50.0(Max Conc. mg/mL);136.46(Max Conc. mM) |
FDA UNII | 212WAX8KDD |
RILPIVIRINE HCL Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
American Custom Chemicals Corporation API0017269 | 5MG | $501.33 | RILPIVIRINE HYDROCHLORIDE 95.00% |
Buy |
RILPIVIRINE HCL Chemical Properties,Usage,Production
Uses
Rilpivirine Hydrochloride was shown to be able to treat and or prevent immunodeficiency virus-1. It also has uses for anti-viral therapyDefinition
ChEBI: A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Used for treatment of HIV.Clinical Use
Rilpivirine hydrochloride (Edurant), a non-nucleoside reverse transcriptase inhibitor (NNRTI), received its approval both from the U.S. FDA and E.U. EMA in 2011 for the treatment of HIV-1 infection in treatment-na?ve adult patients. It was discovered and developed by Janssen Pharmaceuticals and its subsidiary Tibotec Pharmaceuticals. As a second generation NNRTI, rilpivirine hydrochloride displayed higher potency and longer half-life with a 25 mg once a day dose, compared to existing NNRTIs, such as the 200 mg BID of efavirenze (Sustiva). In late 2011, the fixed-dose combination products of rilpivirine hydrochloride with two nucleoside reverse transcriptase inhibitor (RTIs) emtricitabine and tenofovir disoproxil fumarate, co-developed by Gilead Science and Tibotec, were also approved both by the FDA and EMA under brand names Complera® and Eviplera®, respectively.Synthesis
Similar to efavirenze, rilpivirine hydrochloride is a diarylpyrimidine (DAPY) compound, and the large-scale process synthesis begins with commercially available 2-methylthio-4-pyrimidinone (193) shown in the scheme.Thioether 193 was condensed with neat 4-cyanoaniline (194) at elevated temperature to afford diarylamine 195 in 77% yield. Subsequent treatment of pyrimidone 195 with refluxing POCl3 provided the corresponding chloride 196 in 77% yield.160,161 In the presence of K2CO3, chloride 196 was treated with the (E)-cinnamonitrile aniline 200 to give rilpivirine hydrochloride (XIX) in good yield.158 Aniline 200 was prepared via a Heck reaction of commercially available 4-iodo-2,6-dimethyl-benzeneamine (197) and acrylonitrile (198) affording compound 199 as a 4:1 mixture of E/Z isomers. The distribution of E/Z olefins was increased to 98:2 by salt formation and recrystallization to ultimately provide pure (E)-200 in 64% yield for two steps.
Preparation Products And Raw materials
RILPIVIRINE HCL Suppliers
Global(76)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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+1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 | |
+86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 | |
+1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 | |
+1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 | |
+1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 | |
+undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 | |
+86-17063441314 | sansbiotech@outlook.com | China | 677 | 58 | |
+86-852-30606658 | market18@leapchem.com | China | 43348 | 58 | |
+852-53358525 | xena@healthtide-api.com | China | 619 | 58 | |
571-89925085 | sales@amadischem.com | China | 131980 | 58 |
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