Description
Propacetamol is the prodrug of paracetamol (acetaminophen),
used for intravenous administration. It
results from eombination of paracetamol and diethylglycine.
Causes contact dermatitis and airborne dermatitis
in nurses. Allergenic properties are due to the
N,N' -diethylglycine moiety, and not to the paracetamol
moiety.
Uses
Propacetamol hydrochloride is a water-soluble prodrug for intravenous administration resulting in the liberation of paracetamol.
Definition
ChEBI: Propacetamol is an alpha-amino acid ester.
Contact allergens
Propacetamol is a prodrug of paracetamol (acetaminophen)
used for intravenous administration. It results
from the combination of paracetamol and diethylglycine.
It caused contact (hand and airborne) dermatitis in
nurses and acute systemic dermatitis (pompholyx and
nummular dermatitis, generalized eczema, urticaria-like
eruption) in nurses who had became sick and received
intravenous propacetamol. Allergenic properties are due
to the N,N-diethylglycine moiety, and not to the paracetamol
moiety. Propacetamol is now substituted by a
solution of paracetamol in mannitol (Perfalgan?).
Mechanism of action
It is a soluble glycine
prodrug derivative of paracetamol. It is used as
hydrochloride, for intramuscular or intravenous
application and is rapidly metabolized
to free paracetamol .
