Pyridin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Pyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen unter Bildung giftiger Rauche (Stickstoffoxideund Cyanwasserstoff- s. ICSC-Nr. 0492). Schwache Base. Reagiert sehr heftig mit starken Oxidationsmittelnund starken Säuren.

• ARBEITSPLATZGRENZWERTE

  TLV: 1 ppm (als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
  MAK: 5 ppm, 16 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(2); (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf Zentralnervensystem und Magendarmtrakt. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann Bewusstseinstrübung verursachen.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Möglich sind Auswirkungen auf Zentralnervensystem, Leberund Nieren.

• LECKAGE

  Zündquellen entfernen. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Kanalisation spülen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R11:Leichtentzündlich.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S22:Staub nicht einatmen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.

• Aussehen Eigenschaften

  C5H5N; farblose, übelriechende Flüssigkeit.

• Gefahren für Mensch und Umwelt

  Mit Fluor, Halogen/Halogenverbindungen, Chromaten/Perchromate, CrO₃, Salpetersäure, Peroxidverbindungen, Stickstoffoxiden, Schwefeloxide und Anhydriden gefährliche Reaktionen möglich. Bildet im dampf-/gasförmigem Zustand mit Luft explosionsfähige Gemsiche. Leichtentzündlich.
  Verursacht Reizungen an Haut und Schleimhäuten. Nach Verschlucken sind Übelkeit und Kopfschmerzen, in hohen Dosen auch Herz-Kreislaufstörungen, Kollaps und Bewußtlosigkeit möglich. Gefahr der Hautresorption. Bei längerer Exposition werden Leber und Nieren geschädigt. Gute Warnwirkung durch niedrigeGeruchsschwelle. Irreversibler Körperschaden möglich. Erzeugt ernste Reizungen.
  Wassergefährdender Stoff (WGK 2).

• Schutzmaßnahmen und Verhaltensregeln

  Im Abzug arbeiten.
  Latex- oder Neoprenhandschuhe nur als kurzzeitigen Spritzschutz verwenden.

• Verhalten im Gefahrfall

  Mit flüssigkeitsbindendem Material (z.B. Rench Rapid, Chemizorb, Sand) aufnehmen. In dicht verschlossenen Behältern der Entsorgung zuführen. Verschmutzte Gegenstände gründlich Nachreinigen. Dämpfe nicht einatmen, im Notfall Raum evakuieren.
  Wassernebel, Kohlendioxid, Pulver.
  Bei einem Brand können nitrose Gase freigesetzt werden.

• Erste Hilfe

  Nach Hautkontakt: Mit reichlich Wasser abwaschen.
  Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mind. 10 Min. spülen. Sofort Augenarzt hinzuziehen.
  Nach Verschlucken: Erbrechen vermeiden. Aspirationsgefahr! Viel Wasser trinken lassen. Sofort Arzt hinzuziehen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll entsorgen.

• Chemische Eigenschaften

  Pyridine, is a slightly yellow or colorless liquid; hygroscopic; unpleasant odor; burning taste; slightly alkaline in reaction; soluble in water, alcohol, ether, benzene, and fatty oils; specific gravity, 0.978; autoignition temperature, 482 °C. Pyridine, a tertiary amine, is a somewhat stronger base than aniline and readily forms quaternary ammonium salts.

• Chemische Eigenschaften

  Pyridine is a weak base (pK_a= 5.25); a 0.2 M solution has a pH of 8.5 (HSDB 1988). Its carbon atoms are deactivated towards electrophilic substitution. This is especially true in acidic media, where salts form at the nitrogen. It does, however, readily undergo nucleophilic substitution, preferentially at the C-2 and also at the C-4 position (Jori et al 1983). Being a tertiary amine, pyridine reacts with alkylating agents to form quaternary salts (Santodonato et al 1985). Because of its reduced capacity to donate electrons, it is more resistant to oxidation than benzene. Oxidation with peroxy acids forms pyridine N-oxide which is then capable of undergoing electrophilic substitution (Jori et al 1983). Pyridine reacts violently with a number of compounds, including nitric acid, sulfuric acid, maleic anhydride, perchromate, beta-propiolactone and chlorosulfonic acid. Thermal decomposition can liberate cyanides (Gehring 1983). Both the pyridinium ion and pyridine itself are readily reduced to the commercially important compound, piperidine (Jori et al 1983).

• Physikalische Eigenschaften

  Clear, colorless to pale yellow, flammable liquid with a sharp, penetrating, nauseating fish-like odor. Odor threshold concentrations in water and air were 2 ppm (Buttery et al., 1988) and 21 ppb_v (Leonardos et al., 1969), respectively. Detection odor threshold concentrations of 0.74 mg/m³ (2.3 ppm_v) and 6 mg/m³ (1.9 ppm_v) were experimentally determined by Katz and Talbert (1930) and Dravnieks (1974), respectively. Cometto-Mu?iz and Cain (1990) reported an average nasal pungency threshold concentration of 1,275 ppm_v.

• Occurrence

  Pyridine was discovered by Anderson in coal tar in 1846 (Windholz et al 1983). It is found in tobacco smoke (Vohl and Eulenberg 1871; Lehmann 1909) and roasted coffee (Bertrand and Weisweiller 1913). Pyridine is found in wood oil and in the leaves and roots of Atropa belladonna (HSDB 1988), and is also a component of creosote oil (Krone et al 1986). In nature, pyridine and its derivatives are commonly found as components of alkaloids, vitamins, and coenzymes.

• Verwenden

  Pyridine is used directly in the denaturation of alcohol (ACGIH 1986; HSDB 1989; NSC 1978) and as a solvent in paint and rubber preparation (ACGIH 1986; HSDB 1989; NSC 1978) and in research laboratories for functions such as extracting plant hormones (Santodonato et al. 1985). Half of the pyridine produced today is used as an intermediate in making various insecticides and herbicides for agricultural applications (ACGIH 1986; Harper et al. 1985; Santodonato et al. 1985). Approximately 20% goes into the production of piperidine (Harper et al. 1985; Santodonato et al. 1985) which is commercially significant in the preparation of chemicals used in rubber vulcanization and agriculture (NSC 1978). Pyridine is also used as an intermediate in the preparation of drugs (antihistamines, steroids, sulfa-type and other antibacterial agents) dyes, water repellents, and polycarbonate resins (ACGIH 1986; Harper et al. 1985; NSC 1978; Santodonato et al. 1985). Pyridine is also approved by the Food and Drug Administration (FDA) for use as a flavoring agent in the preparation of foods (Harper et al. 1985; HSDB 1989) .

• Verwenden

  Pyridine is used as a solvent in paint andrubber industries; as an intermediate in dyesand pharmaceuticals; for denaturing alcohol;and as a reagent for cyanide analysis. Itoccurs in coal tar.

• Vorbereitung Methode

  Pyridine is produced from the gases obtained by the coking of coal and by direct synthesis. The light-oil fraction of coal tar is treated with sulfuric acid to produce water-soluble pyridine salts and then the pyridine bases are recovered from the aqueous phase by sodium hydroxide or ammonia (Jori et al 1983). The majority of U.S. production is through synthetic means. This process uses a vapor-phase reaction of acetaldehyde, formaldehyde and ammonia, which yields a mixture of pyridine and 3-methylpyridine (Santodonato et al 1985). The product ratio depends on the relative amounts of acetaldehyde and formaldehyde. Added methanol increases the yield. The U.S. production of pyridine was estimated at 32 to 47 million pounds in 1975 (Reinhardt and Brittelli 1981). Pyridine is commercially available in technical, 2° and 1° grades, the latter two referring to their boiling ranges. Major impurities are higher boiling homologues, such as picolines, lutidines and collidines, which are mono-, di-, and trimethylpyridines (Santodonato et al 1985; Jori et al 1983).

• synthetische

  Pyridine is produced either by isolation from natural sources such as coal, or through chemical synthesis (HSDB 1989). Pyridine is produced by the fractional distillation of coal-tar residues (HSDB 1989; NSC 1978; Santodonato et al. 1985) in which 1 ton of coal produces 0.07-0.21 pounds of pyridine bases of which 57% is pyridine (Santodonato et al, 1985). Synthetically produced pyridine is currently the more important source of pyridine for commercial uses (Santodonato et al. 1985). Small amounts of pyridine are synthesized from acetaldehyde, formaldehyde, and ammonia with a fluidized silica-alumina catalyst, followed by fractionation to isolate the pyridine (Harper et al. 1985; HSDB 1989; NSC 1978).
  Pyridine is produced from natural sources by Crowley Tar Products of Stow, Ohio, and Oklahoma City, Oklahoma (Harper et al. 1985; HSDB 1989; SRI 1986, 1987, 1988). Pyridine is synthetically produced by two companies, the Nepera Chemical Co. of Harriman, New York and the Reilly Tar and Chemical Corporation of Indianapolis, Indiana (Harper et al. 1985; SRI 1986, 1987, 1988).

• Definition

  ChEBI: Pyridine is an azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.The molecules have a hexagonal planar ring and are isoelectronic with benzene. Pyridine is an example of an aromatic heterocyclic compound, with the electrons in the carbon–carbon pi bonds and the lone pair of the nitrogen delocalized over the ring of atoms. The compound is extracted from coal tar and used as a solvent and as a raw material for organic synthesis.

• Aroma threshold values

  Detection: 0.079 to 790 ppb; recognition: 7.9 to 40 ppm

• Allgemeine Beschreibung

  A clear colorless to light yellow liquid with a penetrating nauseating odor. Density 0.978 g / cm3. Flash point 68°F. Vapors are heavier than air. Toxic by ingestion and inhalation. Combustion produces toxic oxides of nitrogen.

• Air & Water Reaktionen

  Highly flammable. Soluble in water.

• Reaktivität anzeigen

  Azabenzene is a base. Reacts exothermically with acids. During preparation of a complex of Azabenzene with chromium trioxide, an acid, the proportion of chromium trioxide was increased. Heating from this acid-base reaction led to an explosion and fire [MCA Case History 1284 1967]. A 0.1% solution of Azabenzene (or other tertiary amine) in maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Mixing Azabenzene in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991]. The combination of iodine, Azabenzene, sulfur trioxide, and formamide developed a gas over pressurization after several months. This arose from the slow formation of sulfuric acid from external water, or from dehydration of the formamide to hydrogen cyanide. Ethylene oxide and SO2 can react violently in Azabenzene solution with pressurization if ethylene oxide is in excess (Nolan, 1983, Case History 51).

• Hazard

  Flammable, dangerous fire risk, explosive limits in air 1.8–12.4%. Toxic by ingestion and inhalation. Skin irritant, liver and kidney damage. Questionable carcinogen.

• Health Hazard

  The acute toxicity of pyridine is low. Inhalation causes irritation of the respiratory system and may affect the central nervous system, causing headache, nausea, vomiting, dizziness, and nervousness. Pyridine irritates the eyes and skin and is readily absorbed, leading to systemic effects. Ingestion of pyridine can result in liver and kidney damage. Pyridine causes olfactory fatigue, and its odor does not provide adequate warning of the presence of harmful concentrations.
  Pyridine has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans. Chronic exposure to pyridine can result in damage to the liver, kidneys, and central nervous system.

• Health Hazard

  The toxic effects of pyridine include headache,dizziness, nervousness, nausea, insomnia,frequent urination, and abdominal pain.The symptoms were transient, occurred inpeople from subacute exposure to pyridinevapors at about 125 ppm for 4 hours a dayfor 1–2 weeks (Reinhardt and Brittelli 1981).The target organs to pyridine toxicity are thecentral nervous system, liver, kidneys, gastrointestinaltract, and skin.
  The routes ofexposure are inhalation of vapors, and ingestionand absorption of the liquid throughthe skin. Serious health hazards may arisefrom chronic inhalation, which may causekidney and liver damage, and stimulationof bone marrow to increase the productionof blood platelets. Low-level exposureto 10 ppm may produce chronic poisoningeffects on the central nervous system. Ingestionof the liquid may produce the samesymptoms as those stated above. Skin contactcan cause dermatitis. Vapor is an irritantto the eyes, nose, and lungs. Because of itsstrong disagreeable odor, there is always asufficient warning against any overexposure.A concentration of 10 ppm is objectionableto humans.
  LCLO value, inhalation (rats): 4000 ppm/4 h
  LD50 value, oral (mice): 1500 mg/kg.
  Huh and coworkers (1986) have investigatedthe effect of glycyrrhetinic acid on pyridine toxicity in mice. Pretreatmentwith glycyrrhetinic acid decreaseddepression of the central nervous system andmortality in animals induced by pyridine.Such pretreatment markedly decreased theactivity of the enzyme serum transaminase, and increased the activity of hepaticmicrosomal aniline hydroxylase [9012-90-0], a pyridine- metabolizing enzyme.

• Flammability and Explosibility

  Pyridine is a highly flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance and "flash back." Pyridine vapor forms explosive mixtures with air at concentrations of 1.8 to 12.4% (by volume). Carbon dioxide or dry chemical extinguishers should be used for pyridine fires.

• Industrielle Verwendung

  Pyridine is a good solvent for a large number of compounds, both organic and inorganic (Windholz et al 1983). About 50% of pyridine used in the U.S. is for the production of agricultural chemicals, such as the herbicides paraquat, diquat and triclopyr and the insecticide chlorpyrifos. Other uses are in the production of piperidine; the manufacture of pharmaceuticals, such as steroids, vitamins and antihistamines; and as a solvent. Solvent uses are found in both the pharmaceutical and polycarbonate resin industries. It is particularly useful as a solvent in processes where HC1 is evolved (Santodonato et al 1985). Minor uses for pyridine are for the denaturation of alcohol and antifreeze mixtures, as a dyeing assistant in textiles and as a flavoring agent (Jori et al 1983; Furia 1968; HSDB 1988).

• Kontakt-Allergie

  Pyridine (unsubstituted pyridine) and its derivative (substituted pyridines) are widely used in chemistry. Pyridine is a solvent used for many organic compounds and anhydrous metallic salt chemicals. Contained in Karl Fischer reagent, it induced contact dermatitis in a laboratory technician. No cross-sensitivity is observed between those different substances.

• Sicherheitsprofil

  Poison by intraperitoneal route. Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Mutation data reported. Can cause central nervous system depression, gastrointestinal upset, and liver and kidney damage. A flammable liquid and dangerous fire hazard when exposed to heat, flame, or oxidizers. Severe explosion hazard in the form of vapor when exposed to flame or spark. Reacts violently with chlorosulfonic acid, chromium trioxide, dinitrogen tetraoxide, HNO3, oleum, perchromates, ppropiolactone, AgClO4, H2SO4. Incandescent reaction with fluorine. Reacts to form pyrophoric or explosive products with bromine trifluoride, trifluoromethyl hypofluorite. Mixtures with formamide + iodine + sulfur trioxide are storage hazards, releasing carbon dioxide and sulfuric acid. Incompatible with oxidizing materials. Reacts with maleic anhydride (above 150°C) evolving carbon dioxide. To fight fire, use alcohol foam. When heated to decomposition it emits highly toxic fumes of NOx.

• mögliche Exposition

  Pyridine is used as a solvent in the chemical industry and as a denaturant for ethyl alco- hol; as an intermediate in the production of pesticides; in pharmaceuticals; in the manufacture of paints, explosives, dyestuffs, rubber, vitamins, sulfa drugs; and disinfectants.

• Carcinogenicity

  Pyridine was not carcinogenic in several chronic subcutaneous studies.
  F344 rats were given pyridine orally in drinking water at doses of 0, 7, 14, or 33 mg/kg for 2 years. The top dose produced a decrease in body weights and water consumption. Increased renal tubular adenoma or carcinoma and tubular hyperplasia were observed in males at 33 mg/kg. Increased mononuclear cell leukemia was observed in females at 14 and 33 mg/kg, which was considered equivocal in terms of the relationship to pyridine exposure, since this is a common finding in this strain of rat. Concentration-related nonneoplastic change in the liver was seen at 33 mg/kg. Male Wistar rats were similarly treated with doses of 0, 8, 17, or 36 mg/kg for 2 years. Decreased survival and body weights were seen at 17 and 36 mg/kg. Increased testicular cell adenomas were seen at 36 mg/kg. No changes in survival or neoplasm rates in other tissues, including the kidney, were reported although increased nephropathy and hepatic centrilobular degeneration/necrosis was observed in some pyridine- treated rats.

• Source

  Pyridine occurs naturally in potatoes, anabasis, henbane leaves, peppermint (0 to 1 ppb), tea leaves, and tobacco leaves (Duke, 1992). Identified as one of 140 volatile constituents in used soybean oils collected from a processing plant that fried various beef, chicken, and veal products (Takeoka et al., 1996).

• Environmental Fate

  Biological. Heukelekian and Rand (1955) reported a 5-d BOD value of 1.31 g/g which is 58.7% of the ThOD value of 2.23 g/g. A Nocardia sp. isolated from soil was capable of transforming pyridine, in the presence of semicarbazide, into an intermediate product identified as succinic acid semialdehyde (Shukla and Kaul, 1986). 1,4-Dihydropyridine, glutaric dialdehyde, glutaric acid semialdehyde, and glutaric acid were identified as intermediate products when pyridine was degraded by Nocardia strain Z1 (Watson and Cain, 1975).
  Photolytic. Irradiation of an aqueous solution at 50 °C for 24 h resulted in a 23.06% yield of carbon dioxide (Knoevenagel and Himmelreich, 1976).
  Chemical/Physical. The gas-phase reaction of ozone with pyridine in synthetic air at 23 °C yielded a nitrated salt having the formula: [C6H5NH]+NO3 - (Atkinson et al., 1987). Ozonation of pyridine in aqueous solutions at 25 °C was studied with and without the addition of tert-butyl alcohol (20 mM) as a radical scavenger. With tert-butyl alcohol, ozonation of pyridine yielded mainly pyridine N-oxide (80% yield), which was very stable towards ozone. Without tert-butyl alcohol, the heterocyclic ring is rapidly cleaved forming ammonia, nitrate, and the amidic compound N-formyl oxamic acid (Andreozzi et al., 1991).

• Stoffwechsel

  Pyridine is absorbed through the gastrointestinal tract, skin and lungs and is eliminated via the urine, feces, skin and lungs, both as metabolites and as the parent compound (Jori et al 1983). Uptake by tissues increases with dose and the elimination is biphasic in nature (Zharikov and Titov 1982; HSDB 1988). Elimination is rapid and there appears to be no tissue accumulation (Jori et al 1983). The observation by His (1887) of the urinary excretion of Af-methylpyridine by pyridine-dosed animals was the first example of Af-methylation. Known urinary metabolites of pyridine in mammals now include pyridine N-oxide, N-methyl pyridine, 4-pyridone, 2-pyridone and 3-hydroxypyridine. Some metabolites still remain to be identified (Damani et al 1982). The relative amounts of the metabolites are highly dependent on the species and dose (Gorrod and Damani 1980). For example, the rat has been shown to excrete 70% of a 1 mg/kg dose in the urine in the first 24 h after dosing, but that figure drops to only 5.8% for a 500 mg/kg dose (D'Souza et al 1980). Although urinary excretion of pyridine and its metabolites appears to be a major route for elimination, non-urinary excretion has not been extensively studied (Santodonato et al 1985). In rabbits, the pyridine N-methyltransferase activity has been shown to be highest in lung cytosol and it has been found to utilize 5-adenosyl methionine as the methyl donor (Damani et al 1986). This pathway is saturable in both the rat and the guinea pig (D'Souza et al 1980). The product of this reaction, N-methyl pyridine, is less chronically toxic but more acutely toxic than pyridine (Williams 1959). Pyridine N-oxide is produced by the cytochrome P-450 system and the activity is induced by phenobarbital or pyridine pretreatment but not by 3-methylcholanthrene (Gorrod and Damani 1979; Kaul and Novak 1987). In the rabbit, the alcohol-inducible (and pyridine inducible) P-450 LM_3A appears to be the low K_m isozyme which catalyzes pyridine Af-oxide production (Kim and Novak 1989). The N-oxidation of pyridine may represent a pathway for bioactivation (Santodonato et al 1985) and this pathway becomes more important as the pyridine dose is increased (Damani et al 1982).

• Lager

  Pyridine should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

• Versand/Shipping

  UN1992 Flammable liquids, toxic, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous mate- rials, Technical Name Required.

• läuterung methode

  Likely impurities are H2O and amines such as the picolines and lutidines. Pyridine is hygroscopic and is miscible with H2O and organic solvents. It can be dried with solid KOH, NaOH, CaO, BaO or sodium, followed by fractional distillation. Other methods of drying include standing with Linde type 4A molecular sieves, CaH2 or LiAlH4, azeotropic distillation of the H2O with toluene or *benzene, or treated with phenylmagnesium bromide in ether, followed by evaporation of the ether and distillation of the pyridine. A recommended [Lindauer Mukherjee Pure Appl Chem 27 267 1971] method dries pyridine over solid KOH (20g/Kg) for 2weeks and fractionally distils the supernatant over Linde type 5A molecular sieves and solid KOH. The product is stored under CO2-free nitrogen. Pyridine can be stored in contact with BaO, CaH2 or molecular sieves. Non-basic materials can be removed by steam distilling a solution containing 1.2 equivalents of 20% H2SO4 or 17% HCl until about 10% of the base has been carried over along with the non-basic impurities. The residue is then made alkaline, and the base is separated, dried with NaOH and fractionally distilled. Alternatively, pyridine can be treated with oxidising agents. Thus pyridine (800mL) has been stirred for 24hours with a mixture of ceric sulfate (20g) and anhydrous K2CO3 (15g), then filtered and fractionally distilled. Hurd and Simon [J Am Chem Soc 84 4519 1962] stirred pyridine (135mL), water (2.5L) and KMnO4 (90g) for 2hours at 100o, then stood for 15hours before filtering off the precipitated manganese oxides. Addition of solid KOH (ca 500g) caused pyridine to separate. It was decanted, refluxed with CaO for 3hours and distilled. Separation of pyridine from some of its homologues can be achieved by crystallisation of the oxalates. Pyridine is precipitated as its oxalate by adding it to the stirred solution of oxalic acid in acetone. The precipitate is filtered, washed with cold acetone, and pyridine is regenerated and isolated. Other methods are based on complex formation with ZnCl2 or HgCl2.

• Inkompatibilitäten

  Violent reaction with strong oxidizers; strong acids; chlorosulfonic acid; maleic anhydride; oleum iodine.

• Waste disposal

  Controlled incineration whereby nitrogen oxides are removed from the effluent gas by scrubber, catalytic or thermal devices .

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