GLYCOFUROL

Bezeichnung:GLYCOFUROL

CAS-Nr31692-85-0

Englisch Name:GLYCOFUROL

CBNumberCB7756948

SummenformelC11H21O5R

Molgewicht233.28

MOL-Datei31692-85-0.mol

GLYCOFUROL physikalisch-chemischer Eigenschaften

Siedepunkt	100-145 °C0.4 mm Hg
Dichte	1.09 g/mL at 25 °C(lit.)
Dampfdruck	4.97-37.4Pa at 20-50℃
Brechungsindex	n20/D 1.462(lit.)
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Löslichkeit	Chloroform (Sparingly), Methanol (Slightly, Sonicated)
Aggregatzustand	Oil
Farbe	Colourless
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
LogP	-1.21--0.38

Sicherheit

WGK Germany	3
RTECS-Nr.	MD0907500
HS Code	3907 20 20

Gefahreninformationscode (GHS)

GLYCOFUROL Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Glycofurol is a clear, colorless, almost odorless liquid, with a bitter taste; it produces a warm sensation on the tongue.
Verwenden
Used as solvent to dissolve water-insoluble compounds.
Verwenden
Glycofurol is used as a carrier device for drug delivery.
Vorbereitung Methode
Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol with ethylene oxide (followed by a special purification process in the case of Glycofurol 75).
Pharmazeutische Anwendungen
Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v. It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations. Glycofurol has also been used at 20% v/v concentration in a rectal formulation.
Sicherheit(Safety)
Glycofurol is mainly used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels used as a pharmaceutical excipient. Glycofurol can be irritant when used undiluted; its tolerability is approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a low potential for interaction with hepatoxins or those materials undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg
Lager
Stable if stored under nitrogen in a well-closed container protected from light, in a cool, dry place.
Inkompatibilitäten
Incompatible with oxidizing agents.
Regulatory Status
Included in parenteral medicines licensed in Europe.

GLYCOFUROL Upstream-Materialien And Downstream Produkte

GLYCOFUROL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

31692-85-0, GLYCOFUROL Verwandte Suche:

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