Ibuproxam

ibuproxam Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Ibudros,Manetti-Roberts,Italy,1978

• Verwenden

  rac Ibuproxam is a poorly water-soluble anti-inflammatory drug.

• Definition

  ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of ibuprofen with the amino group of hydroxylamine. Used for treatment of pain and inflammation associated with musculoskeletal and joint disorders.

• Manufacturing Process

  In a 1,000 ml three-necked flask equipped with a stirrer, a dropping funnel and a silica gel guard pipe, 46.7 g hydroxylamine hydrochloride are dissolved cold in 480 ml methanol. Separately a solution of 56.1 g KOH in 280 ml methanol is prepared, heated to 30°C and admixed, dropwise under stirring to the hydroxylamine solution. All successive temperature increases during this admixture are prevented by cooling in an ice bath. After the whole KOH solution has been admixed, the mixture is left standing for 5 minutes so as to attain the complete precipitation of the KCl.
  Separately, 72.02 g ethyl 2-(4-isobutylphenyl)-propionate, obtained by the esterification of 2-(4-isobutylphenyl)-propionic acid with ethanol and concentrated H2SO4, are solved with 100 ml methanol, this solution is introduced drop by drop into the reaction flask, and stirred and cooled for 5 hours on an ice bath. Thereafter it is suction filtered, the residue is washed with all together 50 ml methanol, the wash is added to the filtrate, thereafter the whole is evaporated in a water bath with a rotating evaporator at a reduced pressure, until 100-200 ml of a concentrated solution are obtained. This solution is poured into a 200 ml beaker into which are stirred approximately 1,000 ml 1.25N acetic acid. This mixture is left standing for 24 hours, thereafter suction filtered. The resulting filtrate is taken up with 100 ml petroleum ether at 40°C to 60°C, in order to solve any possible residue of unreacted starting ester, and refiltered. Approximately 50g of 2-(4- isobutylphenyl)-propiohydroxamic acid are obtained, having a melting point of 119°C to 121°C on Kofler's hot stage.

• Therapeutic Function

  Antiinflammatory

ibuproxam Upstream-Materialien And Downstream Produkte

Ibuproxam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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