Diphenoxylathydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H317：Kann allergische Hautreaktionen verursachen.

  H334：Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen.

• Sicherheit

  P262：Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

DIPHENOXYLATE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White or almost white, crystalline powder.

• Originator

  Lomotil,Searle,US,1960

• Verwenden

  Antiperistaltic; antidiarrheal. Controlled substance (opiate).

• Definition

  ChEBI: The hydrochloride salt of diphenoxylate.

• Manufacturing Process

  A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
  omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
  omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

• Therapeutic Function

  Antidiarrheal

• Veterinary Drugs and Treatments

  Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

DIPHENOXYLATE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Diphenoxylathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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