Leptophos (ISO)

Bezeichnung:Leptophos (ISO)

CAS-Nr21609-90-5

Englisch Name:LEPTOMYCIN B

CBNumberCB6293008

SummenformelC13H10BrCl2O2PS

Molgewicht412.07

MOL-Datei21609-90-5.mol

Synonyma

Leptophos

Leptophos (ISO)

Leptophos (ISO) physikalisch-chemischer Eigenschaften

Schmelzpunkt	71-73 °C
Siedepunkt	444.4±55.0 °C(Predicted)
Dichte	1.53 g/cm³ (25 ºC)
Flammpunkt	>100 °C
storage temp.	0-6°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	solid
Farbe	White to Pale Yellow
Wasserlöslichkeit	2.4mg/L(25 ºC)
BRN	2152663
Stabilität	Hygroscopic, Moisture Sensitive
CAS Datenbank	21609-90-5(CAS DataBase Reference)
EPA chemische Informationen	Leptophos (21609-90-5)

Sicherheit

Kennzeichnung gefährlicher	T,N,Xi
R-Sätze:	21-25-39/25-50/53-36/37/38
S-Sätze:	25-36/37/39-45-60-61-23-36-26
RIDADR	2783
WGK Germany	3
RTECS-Nr.	TB1720000
HazardClass	6.1(a)
PackingGroup	II
Giftige Stoffe Daten	21609-90-5(Hazardous Substances Data)
Toxizität	LD50 in adult male, female rats (mg/kg): 19, 20 orally (Gaines, Linder)

Gefahreninformationscode (GHS)

LEPTOMYCIN B Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R21:Gesundheitsschädlich bei Berührung mit der Haut.
R25:Giftig beim Verschlucken.
R39/25:Giftig: ernste Gefahr irreversiblen Schadens durch Verschlucken.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S25:Berührung mit den Augen vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Leptophos is a tan, waxy solid. Molecularweight 5 412.07; Freezing/Melting point =about 70℃.Hazard Identification (based on NFPA-704 M RatingSystem): Health 3, Flammability 1, Reactivity 0. Practicallyinsoluble in water; solubility = 0.028%.
Chemische Eigenschaften
Leptophos is a tan, waxy solid
Verwenden
Insecticide.
Verwenden
Leptomycin B is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory protein Rev at low nanomolar concentrations. It covalently binds to cysteine residue in the center of CRM1/exportin 1 protein.
Definition
ChEBI: O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate is an organic phosphonate that is phenylphosphonothioic O,O-acid in which the hydroxy groups are substituted by methoxy and 4-bromo-2,5-dichlorophenoxy groups. It is a dichlorobenzene, a member of bromobenzenes, an organic phosphonate and a phosphonic ester.
Allgemeine Beschreibung
White crystalline or colorless amorphous solid, the technical product is a light tan powder. Used as an insecticide; its use is not permitted in the U.S.
Reaktivität anzeigen
Organophosphates, such as LEPTOMYCIN B, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
LEPTOMYCIN B is highly toxic; it is capable of causing death or permanent injury by exposure during normal use.
Brandgefahr
(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Container may explode in heat of fire. Fire may produce irritating or poisonous gases. Decomposes above 356F. Avoid strong alkalies.
mögliche Exposition
A potential danger to those involved in the manufacture, formulation and application of this insecticide. Its use is not currently permitted in the United States of America
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, beginrescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. Keepvictim quiet and maintain normal body temperature. Effectsmay be delayed; keep victim under observation.Note to physician: 1,10-trimethylenebis(4-formylpyridiniumbromide)dioxime (a.k.a TMB-4 dibromide and TMV-4) hasbeen used as an antidote for organophosphate poisoning.
Lager
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area.
Versand/Shipping
UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3464 Organophosphorus compound, solid, toxic, n.o.s, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Waste disposal
Small amounts may be treated with alkali then burned in a landfill. Large quantities should be incinerated in a unit with effluent gas scrubbing. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticidecontainers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

21609-90-5, LEPTOMYCIN B Verwandte Suche:

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