Dichloressigsure

Bezeichnung:Dichloressigsure

CAS-Nr79-43-6

Englisch Name:Dichloroacetic acid

CBNumberCB5671951

SummenformelC2H2Cl2O2

Molgewicht128.94

MOL-Datei79-43-6.mol

Synonyma

Dichloressigsure

Bichloressigs?ure

Dichlorethans?ure

Dichloressigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	9-11 °C(lit.)
Siedepunkt	194 °C(lit.)
Dichte	1.56 g/mL at 25 °C (lit.)
Dampfdichte	4.5 (vs air)
Dampfdruck	0.19 mm Hg ( 20 °C)
Brechungsindex	n20/D 1.466(lit.)
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Liquid
pka	1.48(at 25℃)
Farbe	APHA: <50
PH	1.2 (129g/l, H2O, 20℃)
Wasserlöslichkeit	soluble
Sensitive	Hygroscopic
Merck	14,3050
BRN	1098596
Dielectric constant	10.7（-7℃）
Expositionsgrenzwerte	ACGIH: TWA 0.5 ppm (Skin)
Stabilität	Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Reacts with water. Protect from moisture. Hygroscopic.
InChIKey	JXTHNDFMNIQAHM-UHFFFAOYSA-N
LogP	0.92
CAS Datenbank	79-43-6(CAS DataBase Reference)
IARC	2B (Vol. 63, 84, 106) 2014
NIST chemische Informationen	Acetic acid, dichloro-(79-43-6)
EPA chemische Informationen	Dichloroacetic acid (79-43-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,N,C,Xi,F
R-Sätze:	36/38-40-50-35-36/37/38-67-38-65-48/20-11-63-50/53
S-Sätze:	26-45-61-36/37-36-16-62-36/37/39
RIDADR	UN 1764 8/PG 2
WGK Germany	2
RTECS-Nr.	AG6125000
F	3-10
TSCA	Yes
HS Code	2915 40 00
HazardClass	8
PackingGroup	II
Giftige Stoffe Daten	79-43-6(Hazardous Substances Data)
Toxizität	LD50 orally in rats: 2.82 g/kg (Smyth)

Gefahreninformationscode (GHS)

Dichloroacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung giftiger und ätzender Rauche mit Chlorwasserstoff. Starke Säure. Reagiert sehr heftig mit Basen. ätzend. Greift viele Metalle unter Bildung von entzündlichem Wasserstoffgas an.
ARBEITSPLATZGRENZWERTE
TLV: 0.5 ppm (als TWA) Hautresorption Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols und über die Haut.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
ätzend. Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Inhalation des Dampfes kann zu Lungenödem führen (s.Anm.). Exposition kann zum Tod führen. ärztliche Beobachtung notwendig.
LECKAGE
NICHT in die Umwelt gelangen lassen. Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste vorsichtig neutralisieren. Dann mit viel Wasser wegspülen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R50:Sehr giftig für Wasserorganismen.
R35:Verursacht schwere Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
DCA is a corrosive, combustible, colorless liquid with a pungent odor. Molecular weight = 128.94;Specific gravity (H2O:1) = 1.56; Boiling point = 193.8℃;Freezing/Melting point = 9.7-13.5℃; Vaporpressure = 1 mmHg at 44℃; Flash point = 110℃. HazardIdentification (based on NFPA-704 M Rating System):Health 3, Flammability 1, Reactivity 1. Highly corrosive.Soluble in water.
Chemische Eigenschaften
Dichloroacetic acid, CHCI2COOH, also known as dichlorethanoic acid, is a corrosive, combustible, colorless, strong liquid acid with a pungent odor. It is soluble in water and alcohol. Dichloroacetic acid (Ka=5.14 × 10-2) is a stronger acid than chloroacetic acid. Most chemical reactions are similar to those of chloroacetic acid, although both chlorine atoms are susceptible to reaction. Dichloroacetic acid is much more stable to hydrolysis than chloroacetic acid. It is a reactive intermediate in organic synthesis. Dichloroacetic acid is prepared by the chlorination of acetic acid.
Verwenden
Dichloroacetic acid is used as an intermediate to make other chemicals such as its salts and esters. It is involved as a test reagent for fiber analysis and a disinfectant. It is used to inhibit mitochondrial PDK (pyruvate dehydrogenase kinase) and to shift cellular metabolism from glycolysis to glucose oxidation. Further, it is used in the treatment for post-ischemic recovery.
synthetische
Dichloroacetic acid was reported to be first synthesized in 1864 by the further chlorination of monochloroacetic acid with chlorine (Beilstein Online, 2002). The most common production method for dichloroacetic acid is the hydrolysis of dichloroacetyl chloride, which is produced by the oxidation of trichloroethylene.
Application
Dichloroacetic acid (DCA) is a chlorinated acetic acid that has been reported to be a mouse liver carcinogen. The varying degrees of swelling of polyester in different concentrations of DCA solution has been analyzed by phase-contrast microscopy. The efficiency of titanium dioxide (TiO2) nanoparticles to catalyze the photodegradation of DCA has been investigated.
Dichloroacetic acid (DCA) can be used as:
A reactant in the synthesis of chloroketones by reacting with esters in the presence of LiHMDS via Claisen-type homologation reaction.
A structure-directing agent, solvent, or plastdopant for the preparation of different morphologies of polyaniline (PANI). Self-assembling nanostructured PANI may be formed due to the presence of strong hydrogen bonding between DCA and aniline/polyaniline.
Definition
ChEBI: Dichloroacetic acid is an organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis. It has a role as an astringent and a marine metabolite. It is a monocarboxylic acid and an organochlorine compound. It derives from an acetic acid. It is a conjugate acid of a dichloroacetate.
Allgemeine Beschreibung
Dichloroacetic acid appears as a colorless crystalline solid melting at 49°F. Corrosive to metals and tissue.
Air & Water Reaktionen
Soluble in water.
Reaktivität anzeigen
Dichloroacetic acid is probably hygroscopic. Dichloroacetic acid reacts with water or steam. Dichloroacetic acid is incompatible with strong oxidizing agents, strong bases and strong reducing agents.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Flammability and Explosibility
Non flammable
Sicherheitsprofil
Moderately toxic by skin contact and ingestion. It is corrosive to the skin, eyes, and mucous membranes. Questionable carcinogen with experimental tumorigenic data. Will react with water or steam to produce toxic and corrosive fumes. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES.
mögliche Exposition
This haloacetic acid can be a byproduct of drinking water disinfection and may increase the risk of cancer. This chemical is used as starting material for the production of glyoxylic; dialkyloxy acids; and sulfonamides. It is also used as a fungicide, a medication; and a chemical intermediate in pharmaceuticals
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting. Medical observation isrecommended for 2448 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consideradministering a corticosteroid spray.
Lager
Color Code—White: Corrosive or Contact Hazard;Store separately in a corrosion-resistant location. Prior toworking with DCA you should be trained on its proper handling and storage. Store in tightly closed containers in acool, well-ventilated area away from incompatible materialslisted above. Metal containers involving the transfer of thischemical should be grounded and bonded. Where possible,automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped withself-closing valves, pressure vacuum bungs, and flamearresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames,are prohibited where this chemical is used, handled, orstored in a manner that could create a potential fire orexplosion hazard. Wherever this chemical is used, handled,manufactured, or stored, use explosion-proof electricalequipment and fittings.
Versand/Shipping
UN1764 Dichloricacetic acid, Hazard class: 8; Labels: 8-Corrosive material.
läuterung methode
Crystallise this strong acid from *benzene or pet ether. Dry it with MgSO4 and fractionally distil it. [Bernasconi et al. J Am Chem Soc 107 3612 1985, Beilstein 2 IV 498.]
Inkompatibilitäten
DCA is a medium strong acid; incompatible with nonoxidizing mineral acids; organic acids; bases, acrylates, aldehydes, alcohols, alkylene oxides; ammonia, aliphatic amines; alkanolamines, aromatic amines; amides, furfuryl alcohol (explosion hazard), glycols, isocyanates, ketones. Attacks metals generating flammable hydrogen gas. Attacks some plastics, rubber, and coatings

Dichloroacetic acid Upstream-Materialien And Downstream Produkte

Dichloressigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

79-43-6, Dichloroacetic acid Verwandte Suche:

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