Triethyl-O-acetylcitrat

Bezeichnung:Triethyl-O-acetylcitrat

CAS-Nr77-89-4

Englisch Name:Triethyl acetyl citrate

CBNumberCB5483819

SummenformelC14H22O8

Molgewicht318.32

MOL-Datei77-89-4.mol

Synonyma

Triethyl-O-acetylcitrat

Triethyl-O-acetylcitrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	-42°C
Siedepunkt	228-229 °C/100 mmHg (lit.)
Dichte	1.136 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.439(lit.)
Flammpunkt	>230 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Soluble 1 in 140 of water; miscible with acetone, ethanol, and propan-2-ol.
Farbe	Colourless
Geruch (Odor)	odorless
BRN	1804947
LogP	2.170 (est)
CAS Datenbank	77-89-4(CAS DataBase Reference)
NIST chemische Informationen	1,2,3-Propanetricarboxylic acid, 2-acetoxy-, triethyl ester(77-89-4)
EPA chemische Informationen	1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester (77-89-4)

Sicherheit

S-Sätze:	23-24/25
WGK Germany	1
RTECS-Nr.	GE8225000
HS Code	2918150000

Gefahreninformationscode (GHS)

Triethyl acetyl citrate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Acetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.
Verwenden
Triethyl O-Acetylcitrate is used in the preparation of poly(lactic) acid biodegradable and flexible films, acting as a plasticizer. Also used in the synthesis of control-release capsules containing polymeric coatings.
Verwenden
ATEC is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is used as a solvent plasticizer for cellulose nitrate and cellulose acetate.
Vorbereitung Methode
Acetyltriethyl citrate is prepared by the esterification of citric acid with ethanol followed by acylation with acetic anhydride.
Definition
Aqueous-based pharmaceutical coat- ings.
Allgemeine Beschreibung
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Triethyl 2-acetylcitrate is widely used in hydrophilic adhesives for medications and in biodegradable composition for papermaking and nonwoven production.
Pharmazeutische Anwendungen
Acetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations. It is also used in diffusion-controlled release drug delivery systems.
Sicherheit(Safety)
Acetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD₅₀ (cat, oral): 8.5 g/kg
LD₅₀ (mouse, IP): 1.15 g/kg
LD₅₀ (rat, oral): 7 g/kg
Lager
Acetyltriethyl citrate should be stored in dry, closed containers at temperatures not exceeding 388℃. When stored in accordance with these conditions, acetyltriethyl citrate is a stable product.
Inkompatibilitäten
Acetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.
Regulatory Status
Approved in the USA for direct food contact in food films.

Triethyl acetyl citrate Upstream-Materialien And Downstream Produkte

Triethyl-O-acetylcitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

77-89-4, Triethyl acetyl citrate Verwandte Suche:

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