Kasugamycin hydrochloride

Bezeichnung:Kasugamycin hydrochloride

CAS-Nr19408-46-9

Englisch Name:Kasugamycin hydrochloride

CBNumberCB5297221

SummenformelC14H25N3O9.ClH

Molgewicht415.82

MOL-Datei19408-46-9.mol

Kasugamycin hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	202-204 °C (decomp)
Dampfdruck	<1.3x l0^-8 Pa (25 °C)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	H₂O: soluble
pka	3.23 (carboxyl), 7.73 and 11.0 (bases)
Wasserlöslichkeit	125 g l^-1 (25 °C)
Farbe	white to off-white
Stabilität	Hygroscopic
CAS Datenbank	19408-46-9(CAS DataBase Reference)
EPA chemische Informationen	Kasugamycin monohydrochloride (19408-46-9)

Sicherheit

S-Sätze:	22-24/25-26
WGK Germany	2
RTECS-Nr.	NM7521800

Gefahreninformationscode (GHS)

Kasugamycin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Kasugamycin is an aminoglycosidic antibiotic isolated from S. kasugaensis. It blocks the initiation of translation, preventing initiation complex formation on 30S ribosomes in bacteria.
Verwenden
kasugamycin, derived from Streptomyces kasuguensis, is also used to control rice blast.It acts by inhibiting protein synthesis by interfering with the binding of aminoacyl-tRNA to the mRNA-30s ribosomal subunit complex (Yamaguchi, 1998).
Verwenden
antifungal
Verwenden
Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.
in vitro
kasugamycin could inhibit protein synthesis by interacting with the 30s ribosomal subunit. the mechanism of inhibition of protein synthesis appeared to be different from that of other aminoglycosides, such as kanamycin, streptomycin, neomycin, gentamicin. the initiation complex formation on 30s ribosomes could be inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, though the binding of fmet-trna to 70s ribosomes was inhibited by both streptomycin and by kasugamycin. [1].
in vivo
five groups, each consisting of five guinea pigs, were infected with shibaura strain; two groups were treated by injection with kasugamycin. all animals treated with 1 mcg/g were killed showing an average survival period of 7.4 days, which was close to the average survival period of 6.2 days in the control group; while all animals treated with 5 mcg/g survived. the other two groups were treated with kasugamycin from the icteric stage to the 10th day after infection. two animals of the 5 mcg/g group survived, showing no leptospira in the kidney; the other three died in an average of 7.7 days. three animals of the 10 mcg/g group survived; while the other two animals died in 6.5 days on an average . the total amounts of kasugamycin administered to the infected guinea pigs from the febrile stage were 10.8 mg (the 1 mcg/g group) and 54.0 mg (the 5 mcg/g group) [2].
Stoffwechselwegen
kasugamycin hydrochloride hydrate is a relatively stable antibiotic. There is limited published information on its metabolism and environmental fate but it is extensively degraded in plants and soil as indicated in Scheme 1.
Degradation
kasugamycin hydrochloride hydrate is very stable at room temperature. It is stable in weak acids but unstable in strong acids and under basic conditions. Its DT₅₀ values at 50 °C are 47 and 14 days at pH 5 and 9, respectively (PM).
Einzelnachweise
[1] okuyama, a. ,machiyama, n.,kinoshita, t., et al. inhibition by kasugamycin of initiation complex formation on 30s ribosomes. biochemical and biophysical research communications 43(1), 196-199 (1971).
[2] kitaoka m, mori m, arimitsu y. in vitro and in vivo effects of kasugamycin on leptospira icterohaemorrhagiae. jpn j med sci biol. 1975 oct-dec;28(5-6):285-90.

Kasugamycin hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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