Cerdulatinib HCl salt

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Cerdulatinib HCl salt Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an orally active multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 for JAK1/JAK2/JAK3/TYK2 and Syk, respectively nM and 32 nM. Also inhibits 19 other kinases tested with IC50s below 200 nM.

• in vitro

  Cerdulatinib affects BCR-mediated B cell activation through dual inhibition of SYK and JAK in human whole blood from normal donors. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduced cell viability in a subset of NHL cell lines and induced apoptosis in NHL cell lines with BCR signaling.

• in vivo

  In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg po) significantly improved inflammatory infiltration of synovium and articular cartilage integrity. In addition, cerdulatinib also blocked BCR-induced B cell activation and splenomegaly in mice.

• target

  < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> ARK5
  (Cell-free assay)

  Target	Value
  TYK2 (Cell-free assay)	0.5 nM
  MST1 (Cell-free assay)	4 nM
  4 nM
  MLK1 (Cell-free assay)	5 nM
  Fms (Cell-free assay)	5 nM

Cerdulatinib HCl salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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