3-(((Dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-benzolaminium-bromid

Bezeichnung:3-(((Dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-benzolaminium-bromid

CAS-Nr114-80-7

Englisch Name:Neostigmine bromide

CBNumberCB3677212

SummenformelC12H19BrN2O2

Molgewicht303.2

MOL-Datei114-80-7.mol

Synonyma

3-(((Dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-benzolaminium-bromid

3-(((Dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-benzolaminium-bromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	175-177 °C(lit.)
Dichte	1.4344 (rough estimate)
Brechungsindex	1.5410 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H₂O: 1 g/mL
Aggregatzustand	powder
Farbe	white
PH	5.2～6.2 (100g/l, 25℃)
Wasserlöslichkeit	1 g/ mL
Merck	14,6464
BCS Class	3
EPA chemische Informationen	Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (114-80-7)

Sicherheit

Kennzeichnung gefährlicher	T+,T
R-Sätze:	26/27/28-36/37/38-42/43-25
S-Sätze:	22-26-36/37/39-45-37/39-28A
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	BR3150000
HazardClass	6.1(a)
PackingGroup	II
HS Code	29239000

Gefahreninformationscode (GHS)

Neostigmine bromide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:
- to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
- to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
- to study its effects on depolarization of bag cell neurons.
Verwenden
A reversible acetylcholinesterase inhibitor
Verwenden
antiscorbutic, antiviral
Verwenden
Cholinergic; miotic; antidote (curare)
Definition
ChEBI: Neostigmine bromide is the bromide salt of neostigmine. It contains a neostigmine.
Allgemeine Beschreibung
Neostigmine bromide, (m-hydroxyphenyl)trimethylammonium bromide dimethylcarbamateor the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniumbromide (Prostigmin bromide), is usedas an antidote to nondepolarizing neuromuscular blockingdrugs and in the treatment of myasthenia gravis. It occurs asa bitter, odorless, white, crystalline powder. It is soluble inwater and alcohol. The crystals are much less hygroscopicthan those of neostigmine methylsulfate and thus may beused in tablets. Solutions are stable and may be sterilized byboiling. Aqueous solutions are neutral to litmus.
Biologische Aktivität
neostigmine bromide is a reversible inhibitor of acetylcholinesterase.[1]ache (acetylcholinesterase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine at the neuromuscular junction and cholinergic synaspe. it terminates the signal transductions and plays a role in neuronal apoptosis.neostigmine bromide is a quaternary amine that blocked cholinesterase activity to extend and enhance the muscarinic and nicotinic effects of acetylcholine. it is implicated for the treatment of primary open-angle glaucoma, postoperative urinary retention, paralytic ileus, myasthenia gravis etc. it is also reported to be an adjuvant to local anaesthetics and opioids for post-surgical pain after gynaecological or abdominal surgery. [1]
Biochem/physiol Actions
Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.
Clinical Use
Use of physostigmine, as a prototype of an indirect-actingparasympathomimetic drug, facilitated the development ofstigmine, in which a trimethylamine group was placed para toa dimethylcarbamate group in benzene. Better inhibition ofcholinesterase was observed when these groups were placedmeta to each other as in neostigmine, a more active and usefulagent. Although physostigmine contains a methylcarbamatefunctional group, greater chemical stability towardhydrolysis was obtained with the dimethylcarbamyl group inneostigmine.
Sicherheitsprofil
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br-, NH3, and NOx. See also CARBAMATES and BROMIDES.
läuterung methode
Crystallise neostigmine bromide from EtOH/diethyl ether. Its solubility in H2O is ~50%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) The starting material 3-dimethylcarbamoyl-N,N-dimethylaniline [59-99-4] has b 195o/20mm [Beilstein 13 III 936], and its picrate has m 138o (from EtOH).
Einzelnachweise
[1] el-kosasy am, nebsen m, abd el-rahman mk, salem my, el-bardicy mg. comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide. talanta. 2011 aug 15;85(2):913-8.

Neostigmine bromide Upstream-Materialien And Downstream Produkte

3-(((Dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-benzolaminium-bromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

114-80-7, Neostigmine bromide Verwandte Suche:

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