(8α,9R)-6'-methoxycinchonan-9-olmonohydrochlorid

Bezeichnung:(8α,9R)-6'-methoxycinchonan-9-olmonohydrochlorid

CAS-Nr130-89-2

Englisch Name:Quinine hydrochloride

CBNumberCB2453521

SummenformelC20H25ClN2O2

Molgewicht360.88

MOL-Datei130-89-2.mol

Synonyma

(8α,9R)-6'-methoxycinchonan-9-olmonohydrochlorid

(8α,9R)-6'-methoxycinchonan-9-olmonohydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	158-160 C
Dichte	1.1206 (rough estimate)
Brechungsindex	1.5400 (estimate)
FEMA	2976 \| QUININE HYDROCHLORIDE
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	DMSO (Slightly), Ethanol (1g/1ml), glycerol(1g/7ml), chloroform(1g/1ml)
Aggregatzustand	Solid
Farbe	White
Wasserlöslichkeit	549.7mg/L(25 ºC)
InChIKey	LBSFSRMTJJPTCW-QJLYHTAINA-N
SMILES	C12C=C(C=CC=1N=CC=C2[C@@H](O)[C@]1([H])C[C@]2([H])CCN1C[C@@H]2C=C)OC.Cl \|&1:10,12,15,21,r\|
LogP	3.496 (est)
EPA chemische Informationen	Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)- (130-89-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25
RIDADR	1544
HazardClass	6.1(b)
PackingGroup	III
HS Code	29392000
Toxizität	cat,LDLo,intravenous,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927.

Gefahreninformationscode (GHS)

Quinine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.
Verwenden
Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Definition
Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.
Biologische Aktivität
Quinine hydrochloride is a displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine; closely related to chloroquine.?
Sicherheitsprofil
Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.
Synthese
Manufacture of quinine by extraction from Cinchona bark and subsequent purification and synthesis to quinine hydrochloride.
target
Adrenergic Receptor
Lager
Store at -20°C

Quinine hydrochloride Upstream-Materialien And Downstream Produkte

(8α,9R)-6'-methoxycinchonan-9-olmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

130-89-2, Quinine hydrochloride Verwandte Suche:

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