β-Indol-3-ylethanol

Bezeichnung:β-Indol-3-ylethanol

CAS-Nr526-55-6

Englisch Name:Tryptophol

CBNumberCB0782869

SummenformelC10H11NO

Molgewicht161.2

MOL-Datei526-55-6.mol

Synonyma

β-Indol-3-ylethanol

β-Indol-3-ylethanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	56-59 °C(lit.)
Siedepunkt	174 °C (2.02527 mmHg)
Dichte	1.0840 (rough estimate)
Brechungsindex	1.5200 (estimate)
Flammpunkt	255 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	methanol: 0.1 g/mL, clear
pka	15.16±0.10(Predicted)
Aggregatzustand	Crystalline Mass, Crystals, Flakes or Powder
Farbe	Off-white to brown
Wasserlöslichkeit	10 g/L (20 ºC)
Merck	14,9798
BRN	125553
InChIKey	MBBOMCVGYCRMEA-UHFFFAOYSA-N
LogP	1.280 (est)
CAS Datenbank	526-55-6(CAS DataBase Reference)
NIST chemische Informationen	1H-indole-3-ethanol(526-55-6)
EPA chemische Informationen	1H-Indole-3-ethanol (526-55-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	KL3685000
F	8
Hazard Note	Irritant
TSCA	Yes
HS Code	29339990
Toxizität	LD50 intraperitoneal in mouse: 351mg/kg

Gefahreninformationscode (GHS)

Tryptophol Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
3-(2-Hydroxyethyl)indole [526-55-6], tryptophol, C10H11NO, Mr 161.20, mp 59 ℃, bp 174 ℃, (2 kPa) forms colorless prisms or flakes that are readily soluble in methanol, ethanol, diethyl ether, chloroform, and acetone, soluble in benzene, and slightly soluble in water. It is produced by reacting methyl-1H-indole-3-acetate with lithium aluminum hydride, or through reduction of methyl-1H-indole-3-glyoxylate with sodium borohydride. The antihypertensive Indoramin is produced from tryptophol.
Verwenden
Reactant for preparation of:
- Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities
- Anti-HIV-1 agents
- Inhibitors of Protein-Protein Interactions
- Partial agonists of the serotonin 5-HT1A receptor
- Growth hormone secretagogues
- Vascular endothelial growth factor (VEGF) inhibitors
- A2B adenosine receptor ligands
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- Inhibitors of interleukine 6
- Dual binding site acetylcholinesterase inhibitors
Verwenden
Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.
Definition
ChEBI: An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2.
Synthesis Reference(s)
Canadian Journal of Chemistry, 42, p. 485, 1964 DOI: 10.1139/v64-070
läuterung methode
Crystallise it from diethyl ether/pet ether, *C6H6, *C6H6/pet ether. The picrate has m 100-101o (from *C6H6). [Beilstein 21 I 218, 21 II 49, 21 III/IV 788, 21/3 V 61.]

Tryptophol Upstream-Materialien And Downstream Produkte

β-Indol-3-ylethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

526-55-6, Tryptophol Verwandte Suche:

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