(3R-trans)-Dihydro-2,5-dioxofuran-3,4-diyldiacetat

Bezeichnung:(3R-trans)-Dihydro-2,5-dioxofuran-3,4-diyldiacetat

CAS-Nr6283-74-5

Englisch Name:(+)-DIACETYL-L-TARTARIC ANHYDRIDE

CBNumberCB0717661

SummenformelC8H8O7

Molgewicht216.14

MOL-Datei6283-74-5.mol

Synonyma

(3R-trans)-Dihydro-2,5-dioxofuran-3,4-diyldiacetat

(3R-trans)-Dihydro-2,5-dioxofuran-3,4-diyldiacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	130-135 °C(lit.)
Siedepunkt	316.55°C (rough estimate)
Dichte	1.5197 (rough estimate)
Brechungsindex	90 ° (C=0.5, CHCl3)
storage temp.	2-8°C
Löslichkeit	Acetone, Chloroform (Slightly, Heated)
Aggregatzustand	Crystals or Needles
Farbe	White
Optische Aktivität	[α]20/D +59°, c = 6 in acetone
Wasserlöslichkeit	Soluble in methanol and dichloromethane. Slightly soluble in water.
Sensitive	Moisture Sensitive
BRN	87315
CAS Datenbank	6283-74-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
F	3-10-21
HS Code	29321900

Gefahreninformationscode (GHS)

(+)-DIACETYL-L-TARTARIC ANHYDRIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
(+)-O,O′-Diacetyl-L-tartaric anhydride may be used as a chiral derivatizating agent in the following:
- determination of enantiomeric vigabatrin in mouse serum samples using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-M)????????
- determination of trantinterol in rat plasma by ultra performance liquid chromatography–electrospray ionization mass spectrometry (UPLC–MS/MS)
Verwenden
Di-O-acetyl-L-tartaric Anhydride (cas# 6283-74-5) is a compound useful in organic synthesis.
Allgemeine Beschreibung
(+)-O,O′-Diacetyl-L-tartaric anhydride is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed as a reagent for the chiral derivatization of amino alcohols. It also reacts with alkanoamines in aprotic medium containing trichloroacetic acid and produces tartaric acid monoesters.
läuterung methode
If the IR is good, i.e. no OH bands, then keep it in a vacuum desiccator overnight (over P2O5/paraffin) before use. If OH bands are present then reflux 4g in Ac2O (12.6mL) containing a few drops of conc H2SO4 for 10minutes (use a relatively large flask), pour onto ice, collect the crystals, wash with dry *C6H6 (2 x 2mL), stir with 17mL of cold Et2O, filter and dry in it a vacuum desiccator as above, or store it in dark evacuated ampoules under N2 in small aliquots. It is not very stable in air, the melting point of the crystals drop one degree in the first four days then remains constant (132-134o). If placed in a stoppered bottle, it becomes gummy and the m falls 100o in three days. Recrystllisation leads to decomposition. If good quality anhydride is required it, should be prepared freshly from tartaric acid. It sublimes in a CO2 atmosphere. [Shriner & Furrow Org Synth Coll Vol IV 242 1963, Bell Aust J Chem 34 671 1981, Beilstein 18 III/IV 2296.]

(+)-DIACETYL-L-TARTARIC ANHYDRIDE Upstream-Materialien And Downstream Produkte

(3R-trans)-Dihydro-2,5-dioxofuran-3,4-diyldiacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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