醋酸缩宫素

生物活性体内研究醋酸缩宫素试剂级价格

醋酸缩宫素

CAS号:6233-83-6
英文名:Oxytocin acetate
中文名:醋酸缩宫素
CBNumber:CB9927175
分子式:C45H70N12O14S2
分子量:1067.25
MOL File:6233-83-6.mol

醋酸缩宫素化学性质

储存条件 :Store at -20°C
溶解度 :DMSO:44.0(Max Conc. mg/mL);41.23(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);46.85(Max Conc. mM)
形态 :A crystalline solid
InChIKey :DSZOEVVLZMNAEH-SIVBSZNNNA-N

安全信息

危险品运输编号 :UN 2811 6.1 / PGII
海关编码 :2937190000

醋酸缩宫素性质、用途与生产工艺

生物活性 Oxytocin acetate 是一种多效的下丘脑肽 (hypothalamic peptide)，有助于分娩、哺乳和亲社会行为。Oxytocin acetate 可以作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用，特别是在面对逆境或创伤时。

体内研究

During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only.Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s).

Animal Model:	Fifty-six male Lister-hooded rats (150–200 g)
Dosage:	0.1 mg/kg-0.3 mg/kg
Administration:	Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
Result:	Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.

多肽醋酸缩宫素是一种肽类激素。催产素由垂体后叶分泌。由下丘脑室旁核和视上核合成。醋酸缩宫素由9个氨基酸组成和醋酸。生理作用：刺激乳腺分泌乳汁，在分娩过程中促进子宫平滑肌的收缩。此外，它还能减少人体内肾上腺酮等压力激素的水平，以降低血压。
参考质量标准外观:白色粉末
纯度 (HPLC) ≥98.0%
醋酸根含量(HPLC): 6.0%～10.0%
水分含量(Karl Fischer) ≤8.0%