519-23-3
基本信息
玫瑰树碱
5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE
5,11-DIMETHYLPYRIDO[4.3:B]CARBAZOLE
ELLIPTICINE
3-b)carbazole,5,11-dimethyl-6h-pyrido(
icig770
ELLIPTICINE, FOR FLUORESCENCE
ELLIPTICINE(RG)
ELLIPTICIN
PYRIDO(4,3-B)CARBAZOLE,5,11-DIMETHYL-
CP-3025
NSC-71795
物理化学性质
| 熔点 | 316-318°C |
| 沸点 | 379.31°C (rough estimate) |
| 密度 | 1.257±0.06 g/cm3 (20 ºC 760 Torr) |
| 折射率 | 1.5794 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO: soluble |
| 酸度系数(pKa) | 16.59±0.40(Predicted) |
| 形态 | 亮黄色固体 |
| Merck | 13,3581 |
| LogP | 4.800 |
| CAS 数据库 | 519-23-3(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS06 |
| 警示词 | 危险 |
| 危险性描述 | H301 |
| 防范说明 | P264-P270-P301+P310-P405-P501 |
| 危险品标志 | T |
| 危险类别码 | R25 |
| 安全说明 | S45 |
| 危险品运输编号 | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | UU8825000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 毒性 | LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten) |
知名试剂公司产品信息
常见问题列表
|
Topoisomerase II
|
Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.
Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).