Chemical Properties
White Solid
Originator
Drolban,Lilly,US,1961
Uses
An anabolic steroid used as an antineoplastic.
Definition
ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.?
Preparation
Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.
Manufacturing Process
A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous
benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams
of sodium hydride and the mixture was stirred for 5 hours under an
atmosphere of nitrogen and at a temperature of approximately 25°C. The
resulting suspension was filtered, the resulting mixture of the sodium salt of
the hydroxymethylene compound and the excess of sodium hydride was
washed with benzene and dried. This mixture was slowly added to a
vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc
of water, and the stirring was continued for 30 minutes at the end of which
the precipitate was collected and well washed with distilled water. After drying
in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of
pyridine and 2 cc of propionic anhydride was allowed to react at room
temperature for 16 hours and then poured into water. The resulting
suspension was heated for 1 hour on the steam bath to hydrolyze the excess
of propionic anhydride, cooled and extracted with methylene dichloride. The
extract was consecutively washed with dilute hydrochloric acid, sodium
bicarbonate solution and water, dried over anhydrous sodium sulfate and
evaporated to dryness under vacuum. There was thus obtained the
dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated
with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the
solution was evaporated to dryness under vacuum. The residue was dissolved
in a mixture of benzene-hexane, transferred to a chromatographic column
with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture.
Crystallization of the eluates from acetone-hexane yielded the propionate of
2α-methyldihydrotestosterone.
Brand name
Drolban (Lilly).
Therapeutic Function
Cancer chemotherapy
Side effects
As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.
