41879-39-4

mp 62–65°C; bp 87–90°C/40 mmHg.

O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine)is used to induce the cleavage, during solid supported synthesis of hydroxamic acids. It also finds it uses as a chemical additive and an intermediate.

the reagents are most conveniently prepared by treatment of hydroxylamine hydrochloride with ethylenediamine in dichloromethane, followed by the appropriate chlorosilane.A two-step procedure using ammonia in place of ethylenediamine has also been reported.