2,3-二巯基丁二酸（英文缩写为：DMSA），别名2,3-二巯基琥珀酸，是一种有机硫化合物，常温下为白色结晶状粉末。因分子内含有两个巯基，所以它带有巯基化合物特有的臭味。二巯基丁二酸和它的钠盐都可以作为解毒剂通过口服或注射治疗重金属中毒。二巯基丁二酸有两种非对映异构体，一种是内消旋体，另一种是外消旋体。内消旋体可作为螯合剂使用，常用其钠盐。
Succimer (Dimercaptosuccinic acid) 是一种广泛用于研究铅中毒的螯合剂。
Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
化学性质
白色结晶性粉末。熔点196-198℃（分解）。易溶于碱溶液，微溶于甲醇，不溶于水。具有巯基化合物的特臭，在空气中逐渐氧化。
用途
该品是解毒药二巯基丁二酸钠的中间体。
用途
一种镉的选择性掩蔽剂，用于锌的EDTA滴定
用途
用作重金属解毒药、保健药
生产方法
由二溴丁二酸经消除、加成、水解而得。
