F 11440
F 11440 性质
| 沸点 | 517.4±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMF：10.0（最大浓度 mg/mL）；28.95（最大浓度 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.72±0.10(Predicted) |
F 11440 用途与合成方法
|
5-HT 1A Receptor
|
The affinity of Eptapirone (F11440) for 5-HT1Abinding sites (pKi, 8.33) was higher than that of buspirone (pKi , 7.50), and somewhat lower than that of flesinoxan (pKi , 8.91).In vivo, Eptapirone (F11440) was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). Eptapirone (F11440), shown here to be a potent, selective, high efficacy 5-HT1Areceptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.[1]
F 11440 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-19946 | 1 mg | 300 | ||
| 2024-01-25 | HY-19946 | F 11440 | 179756-58-2 | 5mg | 800 |
