2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
![2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 结构式](https://img.chemicalbook.com/CAS/20150408/GIF/223104-29-8.gif)
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 性质
| 沸点 | 485.0±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.254±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 不溶于水； DMSO 中≥18.57 mg/mL； ≥46.4 mg/mL，乙醇溶液，超声波 |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.04±0.10(Predicted) |
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 用途与合成方法
| Target | Value |
|
p38 MAPK
() | |
|
ERK
() | |
|
ROS
() | |
|
NCX
(in cultured astrocytes) | 5.0 nM |
|
NCX
(in cultured microglia) | 8.3 nM |
SEA0400 inhibits Na + -dependent 45 Ca 2+ uptake in cultured neurons, astrocytes, and microglia. IC 50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca 2+ -dependent manner.
SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-15515 | 1 mg | 636 | ||
| 2024-01-25 | HY-15515 | 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 | 223104-29-8 | 5mg | 1400 |
