150493-34-8
150493-34-8 性质
| 沸点 | 476.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：5mg/mL； DMSO：5mg/mL；乙醇：2mg/mL； PBS (pH 7.2)：不溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.15±0.10(Predicted) |
150493-34-8 用途与合成方法
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)
NS-638 dose dependently inhibits K + -stimulated [45 Ca 2+ ]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [ 3 H]GABA-release from cultured cortical neurons with IC 50 values of 2.3 and 4.3 μM, respectively. K + -stimulated intracellular Ca 2+ -elevation in cultured cerebellar granule cells is equipotently blocked with an IC 50 value of 3.4 μM. At this concentration no effect on Ca 2+ -induced contractions in K + -depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca 2+ -channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM.
In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
150493-34-8 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-101428 | 150493-34-8 | 150493-34-8 | 2mg | 500 |
| 2024-01-25 | HY-101428 | 150493-34-8 | 150493-34-8 | 10mM * 1mLin DMSO | 896 |
