基本属性 生物活性靶点体外研究体内研究 用途与合成方法 BAY 607550 价格(试剂级) 供应商
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BAY 607550

BAY 607550

中文名称:BAY 607550
英文名称:BAY 60-7550
CAS号:439083-90-6
分子式:C27H32N4O4
分子量:476.57
EINECS号:
Mol文件:439083-90-6.mol
BAY 607550 结构式

BAY 607550 性质

沸点 680.7±65.0 °C(Predicted)
密度 1.24±0.1 g/cm3(Predicted)
储存条件 -20°C
溶解度 DMSO:21.65(最大浓度 mg/mL);45.43(最大浓度 mM)
乙醇:10.0(最大浓度 mg/mL);20.98(最大浓度 mM)
酸度系数(pKa) 14.54±0.20(Predicted)
形态 粉末
颜色 白色至浅棕色

BAY 607550 用途与合成方法

Bay 60-7550 是有效,选择性的 PDE2 抑制剂,Ki 值为3.8 nM。

Ki: 3.8±0.2 nM (PDE2)

Bay 60-7550 (1 μM) increases cGMP in the neuronal cultures compared with control [F(6,14)=12.97, p<0.05 for Bay 60-7550]. Bay 60-7550 in the presence of NMDA (30 μM) results in further increases in cGMP compared with NMDA alone. The NMDA receptor antagonist MK-801 (10 μM) blocks both Bay 60-7550+NMDA-induced elevation in cGMP in neuronal cultures. Compared with untreated control cells, proliferation of PASMCs from IPAH patients is significantly reduced by BAY 60-7550 (1 μM).

The PDE2 inhibitors Bay 60-7550 (1 mg/kg) reverses restraint stress-induced alterations in behavior, resulting in increased percentages of open-arm entries and open-arm time compared with the vehicle + restraint stress condition. In nonstressed mice, Bay 60-7550 produces a dose-dependent increase in percentages of open-arm entries and open-arm time compared with the vehicle-treated group; significant increases are observed at a dose of 3 mg/kg. In nonstressed mice, Bay 60-7550 increases, in a dose-dependent manner, the number of head-dips and time spent head-dipping, compared with vehicle-treated mice; significant increases are observed at doses of 1 and 3 mg/kg.

BAY 607550 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-14992 1 mg 930
2024-01-25 HY-14992 BAY 607550 439083-90-6 5mg 2046

BAY 607550供应商 更多

北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
英文名称:Bay 60-7550
CAS:439083-90-6
包装信息:2.5Mg,25Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体
武汉丰泰威远科技有限公司
联系电话:027-87465837 19945049750
产品介绍:
英文名称:Bay 60-7550
CAS:439083-90-6
纯度:98%
包装信息:1g,10g,25g,500g,1kg
备注:试剂级
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话:021-61415566 800-8193336
产品介绍:
英文名称:BAY 60-7550
CAS:439083-90-6
纯度:>=95% (HPLC)
包装信息:25MG
备注:SML2311-25MG
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:Bay 60-7550
CAS:439083-90-6
纯度:95%
包装信息:1mg;5mg;10mg
备注:试剂级
北京索莱宝科技有限公司
联系电话:010-50973185 4009686088
产品介绍:
英文名称:Bay 60-7550
CAS:439083-90-6