3-氨基苯甲酰胺
3-氨基苯甲酰胺 性质
| 熔点 | 115-116 °C (lit.) |
|---|---|
| 沸点 | 250.42°C (rough estimate) |
| 密度 | 1.1778 (rough estimate) |
| 折射率 | 1.5769 (estimate) |
| 储存条件 | room temp |
| 溶解度 | 乙醇：50 mg/mL，透明，淡黄色 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 16.26±0.50(Predicted) |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml). |
| 敏感性 | Light Sensitive |
| BRN | 2802373 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
| LogP | -0.330 |
| CAS 数据库 | 3544-24-9(CAS DataBase Reference) |
| NIST化学物质信息 | 3-NH2-C6H4CONH2(3544-24-9) |
3-氨基苯甲酰胺 用途与合成方法
| Target | Value |
|
PARP
() |
3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H 2 O 2 .
In a db/db (Lepr db/db ) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD + depletion and improves water maze performance after controlled cortical impact (CCI) in mice.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36-37/39 |
| 危险品运输编号 | 3077 |
| WGK Germany | 3 |
| RTECS号 | CU8992000 |
| 海关编码 | 29242990 |
| 毒害物质数据 | 3544-24-9(Hazardous Substances Data) |
3-氨基苯甲酰胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-15045 | 3-氨基苯甲酰胺 | 3544-24-9 | 5mg | 970 |
| 2024-01-25 | HY-15045 | 3-氨基苯甲酰胺 | 3544-24-9 | 10mM * 1mLin DMSO | 1070 |
