基本属性 生物活性靶点体外研究体内研究 用途与合成方法 DAMNACANTHAL 价格(试剂级) 供应商 供应信息 相关产品
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DAMNACANTHAL

DAMNACANTHAL

中文名称:DAMNACANTHAL
英文名称:DAMNACANTHAL
CAS号:477-84-9
分子式:C16H10O5
分子量:282.25
EINECS号:
Mol文件:477-84-9.mol
DAMNACANTHAL 结构式

DAMNACANTHAL 性质

熔点 218~219℃
沸点 531.9±50.0 °C(Predicted)
密度 1.461±0.06 g/cm3(Predicted)
储存条件 -20°C
溶解度 溶于DMSO(高达7mg/ml)
酸度系数(pKa) 5.26±0.20(Predicted)
形态 淡橙色固体。
颜色 粘黄色
稳定性 可在-20°C下的DMSO溶液保存长达1个月。

DAMNACANTHAL 用途与合成方法

Damnacanthal 是从 Morinda citrifolia 的根中分离出来的蒽醌。Damnacanthal 是一种强效选择性的 p56lck 酪氨酸激酶活性的抑制剂。天然的 Damnacanthal 抑制 p56lck 的自磷酸化和外源底物的磷酸化,IC50 分别为 46 nM 和 220 nM。Damnacanthal 是一种具有抗癌活性的有效凋亡诱导剂。Damnacanthal 在小鼠中也具有镇痛,抗炎作用,并且对白色念珠菌具有抗真菌活性。

IC50: 46 nM (p56 lck autophosphorylation) and 220 nM (phosphorylation of exogenous substrates by p56 lck );
Apoptosis;
Candida albicans

Damnacanthal has > 100-fold selectivity for p56 lck over the serine/threonine kinases, protein kinase A and protein kinase C, and > 40-fold selectivity for p56 lck over four receptor tyrosine kinases. Damnacanthal also demonstrates modest (7-20-fold), but highly statistically significant, selectivity for p56 lck over the homologous enzymes p60 src and p59 fyn .
Damnacanthal (0.1-100 μM; 1-4 days; HCT-116 and SW480 cells) treatment results in a significant reduction of cell proliferation in a concentration- and time-dependent manner.
Damnacanthal (1-50 μM; 72 hours; HCT-116 cells) treatment results in a significant enrichment in the number of cells in the S/G1 and G2/G1 phases at concentration of 50 μM.
Damnacanthal (10 μM; 24 hours; HCT-116 cells) treatment significantly increases caspase 3/7 activity. Damnacanthal-induced apoptosis.
Damnacanthal (0.1-10 μM; 24 hours; HCT-116 cells) treatment induces NAG-1 expression in HCT-116 cells. Cyclin D1 expression is reduced at 10 μM of Damnacanthal, whereas p21 and p53 does not alter their expression. PARP cleavage is seen at 10 μM Damnacanthal treatment only in HCT-116 cells, where NAG-1 is induced.
Damnacanthal treatment for 2 weeks shows significant decreasing colony number in HCT-116 cells in a concentration-dependent manner. Damnacanthal-treated cells show a dramatic inhibition of clonogenic capacity. Damnacanthal-treated (1-50 μM; 48 hours) cells significantly inhibits the migration of HCT-116 cells in a concentration-dependent manner.

Cell Proliferation Assay

Cell Line: HCT-116 and SW480 cells
Concentration: 0.1 μM, 1 μM, 10 μM, 100 μM
Incubation Time: 1, 2, and 4 days
Result: Resulted in a significant reduction of cell proliferation in a concentration- and time-dependent manner.

Cell Cycle Analysis

Cell Line: HCT-116 cells
Concentration: 1 μM, 10 μM and 50 μM
Incubation Time: 72 hours
Result: Resulted in a significant enrichment in the number of cells in the S/G1 and G2/G1 phases at concentration of 50 μM.

Apoptosis Analysis

Cell Line: HCT-116 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Significantly increased caspase 3/7 activity.

Western Blot Analysis

Cell Line: HCT-116 cells
Concentration: 0.1 μM, 1 μM and 10 μM
Incubation Time: 24 hours
Result: NAG-1 was induced in HCT-116 cells in a dose- and time-dependent manner. Cyclin D1 expression was reduced at 10 μM.

Damnacanthal (10-100 mg/kg; oral administration; for 10-300 minutes; male ddY mice) treatment exhibits a significant antinociceptive effect in a dose-dependent manner in the formalin test. Administration of damnacanthal (100 mg/kg) shows significant inhibition of histamine-induced paw edema.

Animal Model: Male ddY mice (5-6 weeks) injected with formalin or Histamine
Dosage: 10 mg/kg, 30 mg/kg and 100 mg/kg
Administration: Oral administration; for 10 minutes, 30 minutes, 60 minutes or 300 minutes
Result: Significantly reduced the growth of human lung tumor without acute toxicity.

DAMNACANTHAL 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-108485 1 mg 3733
2024-01-25 HY-108485 DAMNACANTHAL 477-84-9 5 mg 9800

DAMNACANTHAL供应商 更多

北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
英文名称:DaMnacanthal
CAS:477-84-9
包装信息:50Mg,5Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体
上海佰世凯化学科技有限公司
联系电话:021-20908456
产品介绍:
英文名称:DaMnacanthal
CAS:477-84-9
备注:C10576
云南西力生物技术股份有限公司
联系电话:0871-65217109 13211707573;
产品介绍:
中文名称:虎刺醛
英文名称:Damnacanthal
CAS:477-84-9
纯度:98.0%
包装信息:5mg
备注:BBP01987
武汉丰泰威远科技有限公司
联系电话:027-87465837 19945049750
产品介绍:
中文名称:丹宁卡
英文名称:Damnacanthal
CAS:477-84-9
纯度:98%
包装信息:1g,10g,25g,500g,1kg
备注:试剂级
武汉天植生物技术有限公司
联系电话:18607101326 15172504745
产品介绍:
中文名称:丹宁卡; 3-羟基-1-甲氧基-2-蒽醌甲醛
英文名称:Damnacanthal
CAS:477-84-9
纯度:>=98%
包装信息:5mg ,10mg ,20mg ,50mg ,100mg; 200mg; 500mg or according to customer requirements
备注:标准品

最新发布供应信息

丹宁卡 Damnacanthal 477-84-9
成都彼样生物科技有限公司 2024-03-26
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上海博湖生物科技有限公司 2023-01-14

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