基本属性 生物活性靶点体外研究体内研究 用途与合成方法 4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 价格(试剂级) 供应商 相关产品
网站主页  化工产品目录 生物化工  生化试剂  激动剂抑制剂  4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺

4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺

4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺

英文名称:FITM
CAS号:932737-65-0
分子式:C18H18FN5OS
分子量:371.43
EINECS号:
Mol文件:932737-65-0.mol
4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 结构式

4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 性质

沸点 573.9±60.0 °C(Predicted)
密度 1.334±0.06 g/cm3(Predicted)
储存条件 Store at -20°C
溶解度 二甲基亚砜:100 mM;乙醇:20mM
形态 结晶固体
酸度系数(pKa) 3.03±0.10(Predicted)

4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 用途与合成方法

FITM是mGlu1受体的负变构调节剂,Ki值为2.5 nM。

mGlu1

2.5 nM (Ki)

FITM fits tightly into the long and narrow pocket. Most of the ligand-receptor interactions are hydrophobic with the exception of the contacts of the pyrimidine-amine group with the T815 7.38 side chain. The mGlu1 binding pocket for FITM largely corresponds to mutagenic data for the common allosteric site in mGlus and likely extends to other class C GPCRs. FITM which shows high affinity and selectivity for mGlu1 over mGlu5. FITM has the high hydrogen bonds occupancy with Thr815 and Tyr805 in dimer A and B of mGlu1 during molecular dynamics simulations. The nitrogen and hydrogen atoms of FITM form the dynamical hydrogen bonds with the hydrogen atom of Tyr805 and oxygen atom of Thr815, respectively. It indicates that there is a strong attraction interaction between FITM and allosteric sites.

The pretreatment of rats with unlabeled FITM (1 mg/kg) occupies an mGluR1 binding site of 18F-FITM by more than 99% and does not affect the input function. The K d (nM) and B max (pmol/mL) obtained by the Scatchard analyses with the multidose ligand assays are 2.1 and 36.3, respectively, for the thalamus; 2.1 and 27.5, respectively, for the hippocampus; 1.5 and 22.2, respectively, for the striatum; and 1.5 and 20.5, respectively, for the cingulate cortex with a high confidence. 18 F-FITM shows excellent pharmacokinetics, namely the dense and specific accumulation in mGlu1-positive melanomas versus mGlu1-negative hepatoma and normal tissues. Furthermore, the accumulation levels of radioactivity corresponded to the extent of tumor and to levels of mGlu1 protein expression in melanomas and melanoma metastasis.

4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-101845 4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 932737-65-0 2mg 500
2024-01-25 HY-101845 4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 932737-65-0 10mM * 1mLin DMSO 740

4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺供应商 更多

江苏艾康生物医药研发有限公司
联系电话:025-66113011 18112977050
产品介绍:
英文名称:4-Fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide
CAS:932737-65-0
纯度:95+%
包装信息:1g;5g;10g
备注:95% HPLC或者GC
盐城希曼生物科技有限公司
联系电话:515-88280676 18921872653
产品介绍:
中文名称:4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺
英文名称:4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide
CAS:932737-65-0
纯度:96%
包装信息:50 g/;100 g/;200 g/;1 KG/;2 KGS/;5 KGS/;10 KGS/;15 KGS/;20 KGS/;25 KGS/
上海瀚香生物科技有限公司
联系电话:17754423994 17754423994
产品介绍:
英文名称:FITM
CAS:932737-65-0
纯度:98% HPLC LCMS
包装信息:100mg;500mg;1g;5g;10g
备注:量大优惠,现货促销
上海超岚化工科技中心
联系电话:QQ:65489617 15618227136
产品介绍:
英文名称:FITM
CAS:932737-65-0
纯度:98%
包装信息:5MG;10MG;50MG;100MG,1G,5G,100G
上海冬洋生物科技有限公司
联系电话:0512-0512-13601744364 13601744364
产品介绍:
英文名称:FITM
CAS:932737-65-0
纯度:98%
包装信息:1g 5g 10g 25g 50g 100g
备注:仅限于科研

"4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺"相关产品信息