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Скополамина гидробромид
- английское имяScopolamine hydrobromide
- CAS №114-49-8
- CBNumberCB9363236
- ФормулаC17H21NO4.BrH
- мольный вес384.26
- EINECS204-050-6
- номер MDLMFCD00012647
- файл Mol114-49-8.mol
химическое свойство
Температура плавления | 195-199 °C (dry matter)(lit.) |
альфа | D25 -24 to -26° (c = 5, calculated on anhydrous basis) |
температура хранения | Store at RT |
растворимость | H2O: 50 mg/mL |
форма | powder |
цвет | white to off-white |
Растворимость в воде | H2O: 100mM |
InChI | InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3 |
ИнЧИКей | WTGQALLALWYDJH-MLRWSLNSNA-N |
SMILES | [C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r| |
Справочник по базе данных CAS | 114-49-8(CAS DataBase Reference) |
FDA 21 CFR | 310.545 |
FDA UNII | R3K67DRL3J |
Система регистрации веществ EPA | Scopolamine hydrobromide (114-49-8) |
UNSPSC Code | 41116107 |
NACRES | NA.77 |
Коды опасности | Xn | |||||||||
Заявления о рисках | 22 | |||||||||
Заявления о безопасности | 36 | |||||||||
РИДАДР | UN 1544 6.1/PG 1 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | YM4550000 | |||||||||
F | 3-8 | |||||||||
кода HS | 2939800000 | |||||||||
Токсичность | LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Скополамина гидробромид химические свойства, назначение, производство
Описание
Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.Химические свойства
Off-White SolidИспользование
An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicantОпределение
ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.Общее описание
Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
Реакции воздуха и воды
Sensitive to air, light and moisture. Water soluble.Профиль реактивности
Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .Пожароопасность
Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.Биологическая активность
Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.Клиническое использование
A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.Методы очистки
The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]Скополамина гидробромид запасные части и сырье
Скополамина гидробромид поставщик
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