1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide

Определение

ChEBI: A carbodiimide having cyclcohexyl and 2-(4-morpholinyl)ethyl as the two N-substituents.

Ссылки на синтез

Synthesis, p. 520, 1987 DOI: 10.1055/s-1987-27992

Синтез

The Preparative Methods of 1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide: from cyclohexyl isothiocyanate and N-(2-aminoethyl)morpholine (67% yield) by dehydration of the corresponding urea with p-Toluenesulfonyl Chloride, Potassium Carbonate, and Benzyltriethylammonium Chloride (91% yield); or by the reaction of cyclohexyl isocyanate, 2-(4-morpholinyl)ethyl diethylphosphoramidate, and potassium carbonate (82% yield).

использованная литература

1. For general reviews on the use of carbodiimides, see (a) Kurzer, F.; Douraghi-Zadeh, K. CRV 1967, 67, 107. (b) Williams, A.; Ibrahim, I. T. CRV 1981, 81, 589. (c) Mikolajczyk, M.; Kielbasinski, P. T 1981, 37, 233.
2. Sheehan, J. C.; Hlavka, J. J. JOC 1956, 21, 439.
3. Jászay, Z. M.; Petneházy, I.; T?ke, L.; Szajáni, B. S 1987, 520.
4. Jászay, Z. M.; Petneházy, I.; T?ke, L.; Szajáni, B. S 1988, 397.