дифенилпиралин

Определение

ChEBI: Diphenylpyraline is a member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold. It has a role as a H1-receptor antagonist and a cholinergic antagonist. It is a member of piperidines and a tertiary amine.

Подготовка

Diphenylpyraline synthesis via coupling of 4-hydroxy-1-methylpiperidine with benzhydrylbromide.

Способ действия

Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms.

использованная литература

[1] H PUHAKKA E V T Rantanen. Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis.[J]. Journal of International Medical Research, 1977, 5 1: 37-41. DOI:10.1177/030006057700500106.
[2] P. RAMAPPA K. G S. Synthesis and Characterization of Copper(II) Complexes with Diphenylpyraline Hydrochloride[J]. Synthesis and Reactivity in Inorganic and Metal-organic Chemistry, 1998, 21 1: 263-274. DOI:10.1080/00945719809351902.
[3] ROBERT WEIS Werner S Andreas J Kungl. Synthesis of new analogues of diphenylpyraline[J]. Tetrahedron, 2003, 59 9: Pages 1403-1411. DOI:10.1016/S0040-4020(03)00072-3.