MK-886
- русский язык имя
- английское имяMK-886
- CAS №118414-82-7
- CBNumberCB8671381
- ФормулаC27H34ClNO2S
- мольный вес472.08
- номер MDLMFCD00876710
- файл Mol118414-82-7.mol
химическое свойство
Температура плавления | 295-297°C |
температура хранения | Sealed in dry,2-8°C |
растворимость | DMSO: 32 mg/mL |
форма | White solid. |
цвет | white |
Стабильность | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
FDA UNII | 080626SQ8C |
MK-886 химические свойства, назначение, производство
Химические свойства
White SolidИспользование
MK-886 is a potent and selective inhibitor of FLAP and Cox-1.Определение
ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.Биологическая активность
An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .MK-886 поставщик
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