diABZI STING agonist-1 trihydrochloride
- русский язык имя
- английское имяdiABZI STING agonist-1 trihydrochloride
- CAS №2138299-34-8
- CBNumberCB84818416
- ФормулаC42H52ClN13O7
- мольный вес886.41
- номер MDLMFCD31746912
- файл Mol2138299-34-8.mol
химическое свойство
температура хранения | Store at -20°C |
растворимость | DMSO: 50 mg/ml |
форма | A crystalline solid |
цвет | White to yellow |
FDA UNII | L7DUG75C36 |
diABZI STING agonist-1 trihydrochloride химические свойства, назначение, производство
Описание
diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC50 = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.diABZI STING agonist-1 trihydrochloride поставщик
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