Famoxadone

Описание

Famoxadone is an oxazolidinedione fungicide. Although famoxadone is not a strobilurin derivative, it shares the same mechanism of action. Famoxadone provides control of a broad spectrum of fungi but is particularly effective against downy mildew (P. viticola), late and early blights (Phytophthora infestans and Alternaria solani), the Septoria complex, and barley net blotch at rates of 50 to 200 g ai/ha. Target crops include vines, potatoes/tomatoes, cereals, sugar beets, canola, and cucumber. It shows good protectant, translaminar and residual control, with excellent rainfastness and good crop safety. As was seen for trifloxystrobin, it is particularly effective against grape downy mildew when applied in mixture with cymoxanil. The cereal disease spectrum and level of disease control are improved when famoxadone is mixed with triazole fungicides such as flusilazole.

Химические свойства

Brown Solid

Использование

Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.

Сельскохозяйственное использование

Fungicide: Tanos 50-DF is recommended for use as a preventative fungicide for control of late blight and early blight on potatoes and field tomatoes.

Торговое название

DPX-JE874®; FAMOXATE®; MEDLEY®; TANOS-50DF®

Фармаколо?гия

Famoxadone inhibits activity of ubiquinol : cytochrome c oxidoreductase at the Qo site of complex III, the same target protein as the strobilurins (34,35). However, studies show a difference in the potency of various strobilurins compared with famoxadone in single amino acid mutants of the cytochrome b protein, suggesting that this compound may interact differently with the target protein (38).

Метаболический путь

Famoxadone undergoes extensive degradation and metabolism in aqueous and soil environments, in wheat plants, rats, goats and hens via common pathways. The primary reactions include the hydrolytic opening of the oxazolidinedione ring, aryl hydroxylation, cleavage of the phenoxyphenyl and the oxazolidinedione-aminophenyl linkages and conjugation. More than 25 degradation products have been identified.