SBE 13 hydrochloride

Описание

SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC₅₀ = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC₅₀ > 66 μM) and Plk3 (IC₅₀ = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC₅₀ = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.

Использование

SBE13 Hydrochloride is a selective inhibitor of PLK1.