3,3',5-трийод-L-тиронин
- английское имя3,3',5-Triiodo-L-thyronine
- CAS №6893-02-3
- CBNumberCB8221269
- ФормулаC15H12I3NO4
- мольный вес650.97
- EINECS229-999-3
- номер MDLMFCD00002593
- файл Mol6893-02-3.mol
химическое свойство
| Температура плавления | 234-238 °C(lit.) |
| альфа | 23 º (c=2 in ethanol) |
| Температура кипения | 232°C (rough estimate) |
| плотность | 2.2155 (estimate) |
| Fp | 9°C |
| температура хранения | -20°C |
| растворимость | DMSO (Slightly), Methanol (Very Slightly) |
| пка | pKa 8.5 (Uncertain);8.4 (Uncertain);8.45 (Uncertain) |
| форма | powder |
| цвет | Off-white to pale yellow |
| оптическая активность | [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2 |
| Растворимость в воде | Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies. |
| Чувствительный | Light Sensitive |
| Мерк | 14,5510 |
| БРН | 2710227 |
| Стабильность | Light Sensitive |
| Справочник по базе данных CAS | 6893-02-3(CAS DataBase Reference) |
| Словарь онкологических терминов NCI | Cytomel |
| FDA UNII | 06LU7C9H1V |
| Словарь наркотиков NCI | Cytomel |
больше
| Коды опасности | Xn,Xi,T,F | |||||||||
| Заявления о рисках | 20/21/22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Заявления о безопасности | 36-26-36/37/39-45-36/37-16 | |||||||||
| РИДАДР | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | AY6750000 | |||||||||
| F | 8 | |||||||||
| кода HS | 29225090 | |||||||||
| Банк данных об опасных веществах | 6893-02-3(Hazardous Substances Data) | |||||||||
| Токсичность | LDLo oral in rat: 7500mg/kg | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H319：При попадании в глаза вызывает выраженное раздражение.
H335：Может вызывать раздражение верхних дыхательных путей.
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оператор предупредительных мер
P261：Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P304+P340：ПРИ ВДЫХАНИИ: Свежий воздух, покой.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P405：Хранить в недоступном для посторонних месте.
3,3',5-трийод-L-тиронин химические свойства, назначение, производство
Описание
Crystalline T3 (liothyronine sodium, Cytomel) has a rapid onset and short duration of action. It is the therapy of choice when it is desirable to have rapid onset or cessation of activity, such as in patients with heart disease.Химические свойства
Off-White SolidИспользование
T3 or 3,3',5-Triiodo-L-thyronine is a thyroid hormone involved with many physiological processes in the human body including growth and development, metabolism, body temperature and heart rate. Free and total T3 serum levels are measured by LC-MS/MS for determination of hyperthyroidism caused by excess T3. This Certified Spiking Solution? is suitable for use as a starting material in preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.Определение
ChEBI: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxi e in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.прикладной
3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.
Биологическая активность
3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.Методы очистки
Likely impurities are as in thyroxine. Purify it by dissolving in dilute NH3 at ~20o, then crystallise it by addition of dilute acetic acid to pH 6. Alternatively 35g are purified by dissolving it in a mixture of EtOH (250mL) and 2N NaOH (100mL), then hot 2N HCl is added to the boiling solution until the pH is 4-5. After cooling for a few hours, the solid is filtered off and dried in a vacuum [m 233-235o(dec)]. [Chambers et al. J Chem Soc 2433 1949, Beilstein 14 III 1566, 14 IV 2373.]3,3',5-трийод-L-тиронин запасные части и сырье
сырьё
3,3',5-трийод-L-тиронин поставщик
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