4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile
- русский язык имя
- английское имя4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile
- CAS №143782-28-9
- CBNumberCB75478496
- ФормулаC13H10F3N3OS
- мольный вес313.3
- файл Mol143782-28-9.mol
химическое свойство
| Температура кипения | 407.3±55.0 °C(Predicted) |
| плотность | 1.48±0.1 g/cm3(Predicted) |
| пка | 10.40±0.40(Predicted) |
4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile химические свойства, назначение, производство
Использование
4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile is used in the preparation of MDV 3100 (Enzalutamide)(M199800) which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.