CHLORPROETHAZINE HYDROCHLORIDE
- русский язык имя
- английское имяCHLORPROETHAZINE HYDROCHLORIDE
- CAS №
- CBNumberCB7525696
- ФормулаC17H20Cl2N2S
- мольный вес355.3251
- файл MolMol file
химическое свойство
| Температура плавления | 179 - 182°C |
| температура хранения | -20°C Freezer |
| растворимость | Chloroform (Slightly), Methanol (Slightly) |
| форма | Solid |
| цвет | White to Off-White |
| FDA UNII | 520P4U8V2Z |
CHLORPROETHAZINE HYDROCHLORIDE химические свойства, назначение, производство
Создатель
Neuriplege, Genevrier ,France,1961Производственный процесс
2-Bromo-2'-(3''-dimethylaminopropyl)-amino-4'-chlorodiphenylsulfide (10 g) is dissolved in dimethylformamide (80 cc). To this solution is added potassium carbonate (5 g) and copper powder (0.4 g). It is then heated under reflux for 48 hours, cooled, and the insoluble matter filtered off. After washing with dimethylformamide (20 cc), the filtrate is taken up in distilled water (200cc). The base formed is extracted with ether (3 times with 50 cc), the ethereal solution is dried over sodium sulfate, the ether driven off on a water-bath and the residue distilled. In this way there is obtained 3-chloro-10-(3'- dimethylaminopropyl)-phenothiazine (6.4 g) which boils at 210 C to 225°C under 0.7 mm of mercury. The hydrochloride is made by the action of ethereal hydrogen chloride on the base dissolved in acetone; this hydrochloride melts at 180°CТерапевтическая функция
Muscle relaxant; Tranquilizer