Lysergic acid diethylamide
- русский язык имя
- английское имяLysergic acid diethylamide
- CAS №50-37-3
- CBNumberCB7418655
- ФормулаC20H25N3O
- мольный вес323.44
- EINECS200-033-2
- номер MDLMFCD00135795
- файл Mol50-37-3.mol
| Температура плавления | 91-93?C |
| альфа | D20 +17° (c = 0.5 in pyridine) |
| Температура кипения | 461.9°C (rough estimate) |
| плотность | 1.1021 (rough estimate) |
| показатель преломления | 1.6200 (estimate) |
| Fp | 2℃ |
| температура хранения | −20°C |
| растворимость | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) |
| форма | Solid |
| пка | pKa 7.5 (Uncertain) |
| цвет | Pale Brown to Brown |
| Стабильность | Stable. Incompatible with strong oxidizing agents. |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 8NA5SWF92O |
| Система регистрации веществ EPA | Lysergide (50-37-3) |
| Коды опасности | T+,T,F,Xn | |||||||||
| Заявления о рисках | 26/27/28-40-36/38-23/25-36-20/21/22-11 | |||||||||
| Заявления о безопасности | 22-28-36-45-33-24-16-7-36/37-26 | |||||||||
| РИДАДР | UN 2811 6.1/PG 1 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | KE4100000 | |||||||||
| Банк данных об опасных веществах | 50-37-3(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in mice, rats, rabbits (mg/kg): 46, 16.5, 0.3 i.v. | |||||||||
| DEA Controlled Substances | CSCN: 7310 CAS SCH: III NARC: N | |||||||||
| DEA Controlled Substances | CSCN: 7310 CAS SCH: III NARC: N | |||||||||
| NFPA 704: |
|
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
опасность
-
вредная бумага
H319：При попадании в глаза вызывает выраженное раздражение.
H225：Легковоспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
H302+H312+H332：Вредно при проглатывании, при попадании на кожу или при вдыхании.
H302+H312：Вредно при проглатывании или при попадании на кожу.
H331：Токсично при вдыхании.
-
оператор предупредительных мер
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P261：Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P302+P352+P312：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Обратиться за медицинской помощью при плохом самочувствии.
P304+P340+P312：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью при плохом самочувствии.
P337+P313：Если раздражение глаз не проходит обратиться за медицинской помощью.
P403+P233：Хранить в хорошо вентилируемом месте в плотно закрытой/герметичной таре.
P403+P235：Хранить в прохладном, хорошо вентилируемом месте.
Lysergic acid diethylamide химические свойства, назначение, производство
Описание
Lysergic acid diethylamide (LSD) is synthetically derived from the fungus, Claviceps purpuria. Several isomers of this compound exist, although only the D-isomer is considered active. LSD was first synthesized by Albert Hofmann in 1938 in a search for an analeptic drug. After finding its psychogenic activity, it was marketed by Sandoz laboratories under the name Delysid?. It was also reportedly used by the Central Intelligence Agency as a tool for interrogation. Due to its potential for ‘bad trips,’ ‘flashbacks,’ and potential risk for brain injury, LSD was banned federally in 1966 and is currently only used illicitly. LSD is chemically similar to other naturally occurring lysergamides found in multiple species of morning glory.Химические свойства
crystalline solidИспользование
LSD is obtained by partial synthesis fromD-lysergic acid. It is also produced bymicrobial reaction of Claviceps paspali overthe hydroxylethylamide. It is a well-knownhallucinogen and a drug of abuse, listed asa controlled substance in the U.S. Code ofFederal Regulations (Title 21, Part 1308.11,1987). It is used as an antagonist to serotoninand in the study and treatment of mentaldisorders.Определение
ChEBI: An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.Общее описание
Prismatic crystals (from benzene). Tasteless and odorless. A hallucinogen.Профиль реактивности
An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).Угроза здоровью
LSD is a strong psychedelic agent. Theeffects in human are excitement, euphoria,hallucinations, and distorted perceptions.It alters the thinking process, producingillusions and loss of contact with reality.In humans, a dose (intramuscular)of 0.7–0.9 mg/kg or an oral dose of2.5–3.0 mg/kg may produce the effectsabove. Other symptoms may include nausea,vomiting, dilation of pupils, restlessness, andperipheral vascoconstriction. However, thereis no reported case of overdose death. In rabbits,somnolence, ataxia, and an increase inbody temperature were the symptoms notedat the LD50 (intravenous) doses at 0.3 mg/kg.LD50 value, intravenous (mice): 46 mg/kg
LD50 value, subcutaneous (guinea pigs):16 mg/kg.
Пожароопасность
Flash point data for LSD are not available; however LSD is probably combustible.Профиль безопасности
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Mutation data reported. Human systemic effects by ingestion and intramuscular routes: euphoria, hallucinations, distorted perceptions, excitement, anorexia, nausea and vomiting. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A much-abused hallucinogen. A federally regulated substance. When heated to decomposition it emits toxic fumes of NOxЭкологическая судьба
LSD may exist in the air or soil. In the air, LSD may be susceptible to photochemical reactions with subsequently induced radical analogs. Photolysis and oxidative degradation may occur with an airborne half-life of 18 min. LSD’s pKa of 7.8 will have a meaningful percentage of the drug in the cationic form allowing it to interact with soil.