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LOGANIC ACID
- русский язык имя
- английское имяLOGANIC ACID
- CAS №22255-40-9
- CBNumberCB7384543
- ФормулаC16H24O10
- мольный вес376.36
- EINECS244-875-9
- номер MDLMFCD00017417
- файл Mol22255-40-9.mol
химическое свойство
Температура кипения | 646.3±55.0 °C(Predicted) |
плотность | 1.60±0.1 g/cm3(Predicted) |
температура хранения | -20°C |
растворимость | Soluble in methan |
форма | powder |
пка | 4.55±0.70(Predicted) |
цвет | White-beige |
LogP | -2.411 (est) |
FDA UNII | UX3J3KK2UG |
LOGANIC ACID химические свойства, назначение, производство
Описание
Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties. Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells. It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml. Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet. It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.Определение
ChEBI: A cyclopentapyran that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1, 6 and 7 by beta-D-glucosyloxy, hydroxy and methyl groups respectivelyLOGANIC ACID поставщик
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