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Индол-3-карбинол
- английское имяIndole-3-carbinol
- CAS №700-06-1
- CBNumberCB7295605
- ФормулаC9H9NO
- мольный вес147.17
- EINECS211-836-2
- номер MDLMFCD02683932
- файл Mol700-06-1.mol
химическое свойство
Температура плавления | 96-99 °C (lit.) |
Температура кипения | 267.28°C (rough estimate) |
плотность | 1.1135 (rough estimate) |
показатель преломления | 1.5670 (estimate) |
температура хранения | 2-8°C |
растворимость | soluble in Methanol |
форма | Crystalline Powder or Flakes |
пка | 15.10±0.10(Predicted) |
цвет | Off-white to yellow-orange |
БРН | 121323 |
Стабильность | 2-80C |
InChI | InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2 |
ИнЧИКей | IVYPNXXAYMYVSP-UHFFFAOYSA-N |
SMILES | N1C2=C(C=CC=C2)C(CO)=C1 |
LogP | 1.366 (est) |
Справочник по базе данных CAS | 700-06-1(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
Словарь онкологических терминов NCI | indole-3-carbinol |
FDA UNII | C11E72455F |
Словарь наркотиков NCI | indole-3-carbinol |
больше
Коды опасности | Xi | |||||||||
Заявления о рисках | 36/38 | |||||||||
Заявления о безопасности | 26-36 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | NL9483000 | |||||||||
Примечание об опасности | Irritant | |||||||||
кода HS | 29339900 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H319:При попадании в глаза вызывает выраженное раздражение.
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оператор предупредительных мер
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Индол-3-карбинол химические свойства, назначение, производство
Химические свойства
Indole-3-carbinol is an off-white powder. It is soluble in organic solvents such as benzene, ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of Indole-3-carbinol in ethanol and DMF is approximately 10 mg/ml and approximately 3 mg/ml in DMSO. Indole-3-carbinol is an unstable compound that undergoes rapid oligomerization in acid pH environments, like the stomach.Вхождение
Indole-3-carbinol is produced by members of the family Cruciferae, and particularly members of the genus Brassica (e.g., cabbage, radishes, cauliflower, broccoli, Brussels sprouts, and daikon).Использование
Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer.Подготовка
Using indole, phosphorus oxychloride and N,N-dimethylformamide as raw materials, indole-3-carbaldehyde was synthesized by Vilsmeier-Haack reaction with a yield of 87.1%.Определение
ChEBI: Indole-3-carbinol is an indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.прикладной
Indole-3-carbinol (I3C) is a secondary plant metabolite of 3-methylindole produced in Brassica family vegetables. It is an inhibitor of Amyloid-beta deposition and Inhibits cancinogenesis at the initiation stage. Indole-3-carbinol is used in cancer prevention, specifically for breast, cervical and colon cancers. It has also been widely used to address lupus.Общее описание
Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts.разработк И противоопухолевых препаратов
I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).Индол-3-карбинол запасные части и сырье
Индол-3-карбинол поставщик
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