НОКАРДАМИН
- английское имяNOCARDAMINE
- CAS №26605-16-3
- CBNumberCB7117055
- ФормулаC27H48N6O9
- мольный вес600.7
- номер MDLMFCD08457937
- файл Mol26605-16-3.mol
химическое свойство
| Температура плавления | 192-195° |
| плотность | 1.162±0.06 g/cm3(Predicted) |
| температура хранения | -20°C |
| растворимость | Soluble in DMSO (5 mg/ml) |
| форма | solid |
| пка | 8?+-.0.20(Predicted) |
| цвет | Off-white |
| Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | Q645668975 |
НОКАРДАМИН химические свойства, назначение, производство
Описание
Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC50 = 9.9 μM). Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.Использование
Nocardamine is a cyclic siderophore.Определение
ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.НОКАРДАМИН поставщик
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