ЭМАДАСТИН ФУМАРАТ

Описание

Emedastine difumarate, a potent H₁-receptor antagonist, was launched in Japan for the treatment of allergic rhinitis and urticaria. Emedastine exerts its antiallergic effect via inhibition of substance P-induced histamine release. It has been demonstrated both in vitro and in vivo that this effect is mediated by the inhibition of Ca²⁺release from extracellular stores and of Ca²⁺ influx into mast cells. In a clinical trial with bronchial asthma, emedastine improved asthmatic symptoms in 55.3% of patients.

Химические свойства

White or yellowish powder

Использование

Antihistaminic, H1-receptor; asthma prophylactic; anti-allergic.

Определение

ChEBI: The fumaric acid salt of emedastine containing two molecules of fumaric acid for each molecule of emedastine. A relatively selective histamine H1 antagonist, it is used for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.

Опасность

A poison by ingestion.