(R) - (+) - 2,2′-Бис (дифенилфосфино) -6,6′-диметокси-1,1′-бифенил

Химические свойства

White powder

Использование

Ligand for ruthenium-catalyzed greener amine synthesis by enamine reduction with hydrogen gas.

Asymmetric Synthesis of (S)-3-Amino-4-methoxy-butan-1-ol by Way of Reductive Amination

Реакции

In many respects the catalytic profile of the MeOBIPHEP ligands is similar to that of other atropisomeric diphosphines such as binap and its many analogs. The nature of the PR2 group strongly influences the catalytic performance of the metal complexes. The rhodium and ruthenium MeO-BIPHEP catalysts are highly effective for the hydrogenation of various C=O, C=C and C=N bonds and several synthetically useful C-C coupling reactions.
Ru and Ir catalyzed dynamic kinetic resolution for the synthesis of hydroxy, amino acid derivatives.

1. 1.Ru-catalyzed asymmetric hydrogenation of ketones and alkenes.
2. Ir catalyzed enantioselective hydrogenation of heteroaromatic compounds.
3. Conjugate addition using 2-heteroaryl titanates and zinc reagents.
4. Enantio- and regioselective heck-type reaction of aryl boronic acids with 2,3-dihydrofuran
5. Rhodium-catalyzed carbonyl Z-dienylation.
6. Rhodium-catalyzed asymmetric 1,4 addition of arylboronic acids to maleimides and enones.

Общее описание

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