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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- русский язык имя
- английское имя2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- CAS №1572936-83-4
- CBNumberCB63049204
- ФормулаC18H14N2O5
- мольный вес338.31
- EINECS-0
- номер MDLMFCD28100806
- файл Mol1572936-83-4.mol
химическое свойство
Температура кипения | 553.1±50.0 °C(Predicted) |
плотность | 1.421±0.06 g/cm3(Predicted) |
температура хранения | Store at -20°C |
растворимость | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble |
форма | A crystalline solid |
пка | 2.26±0.22(Predicted) |
цвет | Brown to dark brown |
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid химические свойства, назначение, производство
Описание
MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.Использование
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid поставщик
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