(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- русский язык имя
- английское имя(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- CAS №1268524-71-5
- CBNumberCB62604226
- ФормулаC23H25ClN4O2S
- мольный вес456.99
- номер MDLMFCD22124456
- файл Mol1268524-71-5.mol
химическое свойство
| Температура кипения | 610.4±65.0 °C(Predicted) |
| плотность | 1.33 |
| температура хранения | 2-8°C |
| растворимость | DMSO: soluble20mg/mL, clear |
| пка | 2.05±0.60(Predicted) |
| форма | powder |
| цвет | white to beige |
| ИнЧИКей | DNVXATUJJDPFDM-QGZVFWFLSA-N |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate химические свойства, назначение, производство
Использование
(R)-(-)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate is the enantiomer of (S)-(+)-Tert-butyl 2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (T117580), which is BET bromodomain inhibitor, also activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.Общее описание
JQ1 is a member of the triazolo-diazepine compound family which functions as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. Its core structure is composed of thienodiazepine.(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate запасные части и сырье
сырьё
- (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- N-Fmoc-L-аспарагиновой кислоты 4-трет-бутиловый эфир
- Ацетгидразид
- (±)-JQ1
- 1H-Thieno[2,3-e]-1,4-diazepine-3-acetic acid, 5-(4-chlorophenyl)-2,3-dihydro-6,7-diMethyl-2-oxo-, 1,1-diMethylethyl ester, (3S)-
- Бутановая кислота, 3-амино-4 - [[3- (4-хлорбензоил) -4,5-диметил-2-тиенил] амино] -4-оксо-, 1,1-диметилэтиловый эфир, (3S) -
- 2-АМИно-3-(п-хлорбензоил)-4,5-диметилтиофен
- Butanoic acid, 4-[[3-(4-chlorobenzoyl)-4,5-diMethyl-2-thienyl]aMino]-3-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]-4-oxo-, 1,1-diMethylethyl ester, (3S)-
1of2
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate поставщик
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